Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
The Influence of Proteins on Fate and Biological Role of Circulating DNA. / Tutanov, Oleg; Tamkovich, Svetlana.
в: International Journal of Molecular Sciences, Том 23, № 13, 7224, 01.07.2022.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
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TY - JOUR
T1 - The Influence of Proteins on Fate and Biological Role of Circulating DNA
AU - Tutanov, Oleg
AU - Tamkovich, Svetlana
N1 - Funding Information: This research was funded by a grant from the Russian Science Foundation, N22‐25‐00130, https://rscf.ru/project/22‐25‐00130/. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/7/1
Y1 - 2022/7/1
N2 - Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.
AB - Circulating DNA has already proven itself as a valuable tool in translational medicine. However, one of the overlooked areas of circulating DNA research is its association with different proteins, despite considerable evidence that this association might impact DNA’s fate in circulation and its biological role. In this review, we attempt to shed light on current ideas about circulating DNA origins and forms of circulation, known biological effects, and the clinical potential of circulating tumor deoxyribonucleoprotein complexes.
KW - cell surface‐bound DNA
KW - cell‐free tumor DNA
KW - circulating DNA
KW - DNA‐binding proteins
KW - exosomes
KW - extracellular vesicles
KW - Humans
KW - Cell-Free Nucleic Acids/metabolism
KW - Exosomes/metabolism
KW - Neoplasms/genetics
UR - http://www.scopus.com/inward/record.url?scp=85133127525&partnerID=8YFLogxK
UR - https://www.mendeley.com/catalogue/057119a5-c284-3d0c-bedf-f2caa029b5b0/
U2 - 10.3390/ijms23137224
DO - 10.3390/ijms23137224
M3 - Review article
C2 - 35806228
AN - SCOPUS:85133127525
VL - 23
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 13
M1 - 7224
ER -
ID: 36541564