Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава (рецензируемая) › Рецензирование
The Inflammation in Schizophrenia: Biomarkers and Association with Pathogenesis. / Ermakov, Evgeny A.; Buneva, Valentina N.; Ivanova, Svenlana A.
Handbook of the Biology and Pathology of Mental Disorders. ред. / Colin R. Martin; Victor R. Preedy; Vinood B. Patel; Rajkumar Rajendram. Springer Nature, 2025. стр. 2505-2531 112 (Handbook of the Biology and Pathology of Mental Disorders).Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › глава (рецензируемая) › Рецензирование
}
TY - CHAP
T1 - The Inflammation in Schizophrenia: Biomarkers and Association with Pathogenesis
AU - Ermakov, Evgeny A.
AU - Buneva, Valentina N.
AU - Ivanova, Svenlana A.
N1 - Ermakov, E.A., Buneva, V.N., Ivanova, S.A. (2025). The Inflammation in Schizophrenia: Biomarkers and Association with Pathogenesis. In: Martin, C.R., Preedy, V.R., Patel, V.B., Rajendram, R. (eds) Handbook of the Biology and Pathology of Mental Disorders. Springer, Cham. https://doi.org/10.1007/978-3-031-73368-0_112
PY - 2025/8/31
Y1 - 2025/8/31
N2 - Multiple lines of evidence are known to implicate inflammation to schizophrenia. This chapter summarizes the evidence for changes in inflammatory biomarkers and the role of inflammation in schizophrenia. Current evidence indicates changes in immune biomarkers at all stages of schizophrenia, from clinical high-risk for psychosis individuals to chronic patients. Antipsychotic therapy also affects immune biomarkers. Inflammatory parameters are associated with positive and negative symptoms, cognitive impairment, and structural brain abnormalities. Mendelian randomization studies have provided evidence of causal links between inflammation and schizophrenia. Neuroinflammation contributes to neurotransmitter abnormalities, oxidative stress, and functional dysconnectivity in the brain. The involvement of chronic low-grade inflammation in the pathogenesis of schizophrenia opens new possibilities for personalized anti-inflammatory therapy in schizophrenia.
AB - Multiple lines of evidence are known to implicate inflammation to schizophrenia. This chapter summarizes the evidence for changes in inflammatory biomarkers and the role of inflammation in schizophrenia. Current evidence indicates changes in immune biomarkers at all stages of schizophrenia, from clinical high-risk for psychosis individuals to chronic patients. Antipsychotic therapy also affects immune biomarkers. Inflammatory parameters are associated with positive and negative symptoms, cognitive impairment, and structural brain abnormalities. Mendelian randomization studies have provided evidence of causal links between inflammation and schizophrenia. Neuroinflammation contributes to neurotransmitter abnormalities, oxidative stress, and functional dysconnectivity in the brain. The involvement of chronic low-grade inflammation in the pathogenesis of schizophrenia opens new possibilities for personalized anti-inflammatory therapy in schizophrenia.
UR - https://www.scopus.com/pages/publications/105023351184
UR - https://www.mendeley.com/catalogue/47051e72-dbc2-33ed-8a0f-019b3b2ae7cd/
U2 - 10.1007/978-3-031-73368-0_112
DO - 10.1007/978-3-031-73368-0_112
M3 - Chapter (peer-reviewed)
SN - 978-3-031-73367-3
T3 - Handbook of the Biology and Pathology of Mental Disorders
SP - 2505
EP - 2531
BT - Handbook of the Biology and Pathology of Mental Disorders
A2 - Martin, Colin R.
A2 - Preedy, Victor R.
A2 - Patel, Vinood B.
A2 - Rajendram, Rajkumar
PB - Springer Nature
ER -
ID: 72465427