Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The impact of early-life stress on the expression of HPA-associated genes in the adult murine brain. / Reshetnikov, V. V.; Studenikina, A. A.; Ryabushkina, J. A. и др.
в: Behaviour, Том 155, № 2-3, 01.01.2018, стр. 181-203.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The impact of early-life stress on the expression of HPA-associated genes in the adult murine brain
AU - Reshetnikov, V. V.
AU - Studenikina, A. A.
AU - Ryabushkina, J. A.
AU - Merkulova, T. I.
AU - Bondar, N. P.
N1 - Publisher Copyright: © 2018 Copyright 2018 by Koninklijke Brill NV, Leiden, The Netherlands.
PY - 2018/1/1
Y1 - 2018/1/1
N2 - Early life is an important period for the development of the nervous system and for the programming of behavioural phenotypes in adulthood. In our study, two types of early-life stress were used: prolonged separation of pups from their mothers (for 3 h/day, maternal separation (MS)) and brief separation (for 15 min/day, handling (HD)). We analysed the effects of early-life stress on behaviour and the expression of HPA-associated genes in the hypothalamus, hippocampus, and frontal cortex of male mice. Adult mice in the MS group demonstrated reduced locomotor activity and deficiencies in spatial long-term memory, while the HD showed no significant changes. Additionally, early-life MS resulted in reduced hippocampal Crhr1 mRNA, increased MR/GR mRNA in the hippocampus and hypothalamus. Both groups, HD and MS, showed increased Avp mRNA in the hypothalamus. Thus, prolonged maternal separation but not brief leads to adverse behavioural changes and influences the expression of HPA-associated genes in a brain region-specific manner.
AB - Early life is an important period for the development of the nervous system and for the programming of behavioural phenotypes in adulthood. In our study, two types of early-life stress were used: prolonged separation of pups from their mothers (for 3 h/day, maternal separation (MS)) and brief separation (for 15 min/day, handling (HD)). We analysed the effects of early-life stress on behaviour and the expression of HPA-associated genes in the hypothalamus, hippocampus, and frontal cortex of male mice. Adult mice in the MS group demonstrated reduced locomotor activity and deficiencies in spatial long-term memory, while the HD showed no significant changes. Additionally, early-life MS resulted in reduced hippocampal Crhr1 mRNA, increased MR/GR mRNA in the hippocampus and hypothalamus. Both groups, HD and MS, showed increased Avp mRNA in the hypothalamus. Thus, prolonged maternal separation but not brief leads to adverse behavioural changes and influences the expression of HPA-associated genes in a brain region-specific manner.
KW - frontal cortex
KW - gene expression
KW - hippocampus
KW - HPA
KW - hypothalamus
KW - maternal separation
KW - mice
UR - http://www.scopus.com/inward/record.url?scp=85045381750&partnerID=8YFLogxK
U2 - 10.1163/1568539X-00003482
DO - 10.1163/1568539X-00003482
M3 - Article
AN - SCOPUS:85045381750
VL - 155
SP - 181
EP - 203
JO - Behaviour
JF - Behaviour
SN - 0005-7959
IS - 2-3
ER -
ID: 12560724