Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
The Effects of Short-Term Stress and Long-Term Fluoxetine Treatment on the Expression of Apoptotic Proteins in the Brain. / Dygalo, N. N.; Kalinina, T. S.; Shishkina, G. T.
в: Neurochemical Journal, Том 12, № 2, 04.2018, стр. 155-158.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - The Effects of Short-Term Stress and Long-Term Fluoxetine Treatment on the Expression of Apoptotic Proteins in the Brain
AU - Dygalo, N. N.
AU - Kalinina, T. S.
AU - Shishkina, G. T.
PY - 2018/4
Y1 - 2018/4
N2 - The effects of 2- or 8-week-long daily treatment with fluoxetine at a dose of 7.26-7.70 mg/kg given with drinking water and short-term forced-swim stress on the levels of mRNAs of anti- and pro-apoptotic proteins, that is, Bcl-xL and Bax, respectively, were studied in the brains of adult male rats using the RT-PCR method. Antiapoptotic effects of stress on the expression of these proteins were observed in the hippocampus of rats that were not treated with fluoxetine and in the midbrain after 2 weeks of the antidepressant treatment. Pro-apoptotic effects of stress were revealed in the frontal cortex of animals that were not treated with fluoxetine and after 2 weeks of fluoxetine treatment. An 8-week-long fluoxetine treatment resulted in an increase in the basal Bax expression in the hippocampus and in anti-apoptotic effects in the neocortex, which were more clearly seen after stress. The observed interaction of the effects of stress and fluoxetine on the expression of proteins of neuronal survival and plasticity may provide anti- or proapoptotic action of the antidepressant on the cells of the emotiogenic structures of the brain.
AB - The effects of 2- or 8-week-long daily treatment with fluoxetine at a dose of 7.26-7.70 mg/kg given with drinking water and short-term forced-swim stress on the levels of mRNAs of anti- and pro-apoptotic proteins, that is, Bcl-xL and Bax, respectively, were studied in the brains of adult male rats using the RT-PCR method. Antiapoptotic effects of stress on the expression of these proteins were observed in the hippocampus of rats that were not treated with fluoxetine and in the midbrain after 2 weeks of the antidepressant treatment. Pro-apoptotic effects of stress were revealed in the frontal cortex of animals that were not treated with fluoxetine and after 2 weeks of fluoxetine treatment. An 8-week-long fluoxetine treatment resulted in an increase in the basal Bax expression in the hippocampus and in anti-apoptotic effects in the neocortex, which were more clearly seen after stress. The observed interaction of the effects of stress and fluoxetine on the expression of proteins of neuronal survival and plasticity may provide anti- or proapoptotic action of the antidepressant on the cells of the emotiogenic structures of the brain.
KW - Bcl-xL
KW - Bax
KW - midbrain
KW - hippocampus
KW - frontal cortex
KW - fluoxetine
KW - forced-swim test
KW - UP-REGULATION
KW - RAT-BRAIN
KW - BCL-XL
KW - PLASTICITY
KW - NEURONS
KW - RESILIENCE
KW - DEPRESSION
KW - BEHAVIOR
KW - HORMONES
KW - DISEASE
U2 - 10.1134/S1819712418020034
DO - 10.1134/S1819712418020034
M3 - Article
VL - 12
SP - 155
EP - 158
JO - Neurochemical Journal
JF - Neurochemical Journal
SN - 1819-7124
IS - 2
ER -
ID: 18647667