TY - JOUR

T1 - The Effects of Chronic Stress on Brain Myelination in Humans and in Various Rodent Models

AU - Antontseva, Elena

AU - Bondar, Natalia

AU - Reshetnikov, Vasiliy

AU - Merkulova, Tatiana

N1 - This work was supported by the Russian Science Foundation [grant #16-15-10131]. Copyright © 2020 IBRO. Published by Elsevier Ltd. All rights reserved.

PY - 2020/8/10

Y1 - 2020/8/10

N2 - The myelination of axons, which is performed in brain tissues by specialized glial cells (oligodendrocytes) is crucial for correct formation of the complicated neural circuitry necessary for normal cognition, sensation, and motor function. Myelin-related anomalies are seen in many neurodegenerative diseases and in psychiatric disorders, including major depressive disorder and post-traumatic stress disorder. Chronic stress involving chronic stress early in life is believed to be a major etiological factor of neuropsychiatric disorders. Although molecular and cellular mechanisms underlying stress-induced psychopathologies are actively investigated, there is still little data about the role that is played in the development of these pathologies by myelin and oligodendrocyte impairments caused by chronic stress. In this article, after brief review of published data on myelin abnormalities in stress-related psychiatric disorders, we focus on recent cellular and molecular discoveries in various rodent models including models of chronic unpredictable stress, social isolation stress, chronic social defeat stress, and chronic immobilization stress. We also attempt to compile and analyze currently scarce data on myelin-related impairments resulting from early postnatal stress.

AB - The myelination of axons, which is performed in brain tissues by specialized glial cells (oligodendrocytes) is crucial for correct formation of the complicated neural circuitry necessary for normal cognition, sensation, and motor function. Myelin-related anomalies are seen in many neurodegenerative diseases and in psychiatric disorders, including major depressive disorder and post-traumatic stress disorder. Chronic stress involving chronic stress early in life is believed to be a major etiological factor of neuropsychiatric disorders. Although molecular and cellular mechanisms underlying stress-induced psychopathologies are actively investigated, there is still little data about the role that is played in the development of these pathologies by myelin and oligodendrocyte impairments caused by chronic stress. In this article, after brief review of published data on myelin abnormalities in stress-related psychiatric disorders, we focus on recent cellular and molecular discoveries in various rodent models including models of chronic unpredictable stress, social isolation stress, chronic social defeat stress, and chronic immobilization stress. We also attempt to compile and analyze currently scarce data on myelin-related impairments resulting from early postnatal stress.

KW - chronic immobilization stress

KW - chronic social stress

KW - chronic unpredictable stress

KW - early-life stress

KW - hypomyelination

KW - medial prefrontal cortex

KW - SOCIAL-ISOLATION

KW - VIDEO ANALYSIS

KW - DEPRESSION

KW - PROTEOME MAP

KW - CHRONIC MILD STRESS

KW - RESCUES BEHAVIORAL-CHANGES

KW - PREFRONTAL CORTEX

KW - MOUSE MODEL

KW - GENE-EXPRESSION

KW - WHITE-MATTER ABNORMALITIES

UR - http://www.scopus.com/inward/record.url?scp=85087740058&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/d65431fb-8d0b-39f3-85c5-41352ee89e0b/

U2 - 10.1016/j.neuroscience.2020.06.013

DO - 10.1016/j.neuroscience.2020.06.013

M3 - Review article

C2 - 32562745

AN - SCOPUS:85087740058

VL - 441

SP - 226

EP - 238

JO - Neuroscience

JF - Neuroscience

SN - 0306-4522

ER -