Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Terahertz nanoantenna sensor for detection of biomarker L-2-Hydroxyglutarate, design optimization and testing. / Черкасова, Ольга Павловна; Кузнецов, Сергей Александрович; Рыбак, Алина Анатольевна и др.
в: Optical and Quantum Electronics, Том 57, № 6, 340, 26.05.2025.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Terahertz nanoantenna sensor for detection of biomarker L-2-Hydroxyglutarate, design optimization and testing
AU - Черкасова, Ольга Павловна
AU - Кузнецов, Сергей Александрович
AU - Рыбак, Алина Анатольевна
AU - Конникова, M. Р.
AU - Utkin, Dmitry
AU - Николаев, Назар Александрович
N1 - Terahertz nanoantenna sensor for detection of biomarker L-2-Hydroxyglutarate, design optimization and testing / O. P. Cherkasova, S. A. Kuznetsov, A. A. Rybak [et al.] // Optical and Quantum Electronics. – 2025. – Vol. 57. - No. 6. – DOI 10.1007/s11082-025-08260-7. – EDN AUGNBO. This work was performed partly within the State Assignment of IA&E SB RAS, Lomonosov Moscow State University, and NRC “Kurchatov Institute” (in terms of THz sensor testing) and within the project FSUS-2024-0020 of the Ministry of Science and Higher Education of the Russian Federation (in terms of antenna design development and simulation).
PY - 2025/5/26
Y1 - 2025/5/26
N2 - L-2-Hydroxyglutarate (L-2HG) plays a significant role in many physiological processes and is considered as a biomarker for various types of oncology. So, its rapid and quantitative measurement in tissues and body fluids is of great clinical importance. The goal of this work is to develop highly efficient photonic sensor for L-2HG using the effect of nanoantenna-assisted plasmonic enhancement of terahertz absorption. We present the numerical results of the design optimization for L-2HG sensor based on Si/SiO2-wafer-backed arrays of golden nanoantennas (NA) of linear geometry for the resonant frequency of 1.337 THz. NA sensor was fabricated by nanolithography, characterized by scanning electron microscope and tested with terahertz time-domain spectroscopy (THz-TDS). Experimental validation of the NA sensor showed its specific sensitivity to L-2HG. A number of methods have been proposed to improve the accuracy of the NA sensor characterized using THz-TDS technique by an order of magnitude.
AB - L-2-Hydroxyglutarate (L-2HG) plays a significant role in many physiological processes and is considered as a biomarker for various types of oncology. So, its rapid and quantitative measurement in tissues and body fluids is of great clinical importance. The goal of this work is to develop highly efficient photonic sensor for L-2HG using the effect of nanoantenna-assisted plasmonic enhancement of terahertz absorption. We present the numerical results of the design optimization for L-2HG sensor based on Si/SiO2-wafer-backed arrays of golden nanoantennas (NA) of linear geometry for the resonant frequency of 1.337 THz. NA sensor was fabricated by nanolithography, characterized by scanning electron microscope and tested with terahertz time-domain spectroscopy (THz-TDS). Experimental validation of the NA sensor showed its specific sensitivity to L-2HG. A number of methods have been proposed to improve the accuracy of the NA sensor characterized using THz-TDS technique by an order of magnitude.
KW - Terahertz time-domain spectroscopy
KW - Nanoantenna sensor
KW - Molecular biomarkers
KW - L-2-Hydroxyglutarate
UR - https://elibrary.ru/item.asp?id=82917468
U2 - 10.1007/s11082-025-08260-7
DO - 10.1007/s11082-025-08260-7
M3 - Article
VL - 57
JO - Optical and Quantum Electronics
JF - Optical and Quantum Electronics
SN - 0306-8919
IS - 6
M1 - 340
ER -
ID: 73778522