TY - JOUR

T1 - Template-directed crystallization of carbamazepine form II from palmitic acid melt - a key to understand mechanically-induced polymorphism of carbamazepine

AU - Losev, Evgeniy A.

AU - Zheltikova, Daria Ya

AU - Drebushchak, Valeri A.

AU - Boldyreva, Elena V.

N1 - This work was supported by the Russian Science Foundation, grant no. 24-13-00140, https://rscf.ru/en/project/24-13-00140/. The equipment of the Chair of Solid-State Chemistry and Laboratory MDEST of the REC INChT, Novosibirsk State University was used.

PY - 2024/11/30

Y1 - 2024/11/30

N2 - Heating a single crystal of carbamazepine (III) (the thermodynamically stable form) in contact with solid palmitic acid resulted in the melting of palmitic acid and the growth of the crystals of carbamazepine (II) (the least stable polymorph) at the interface “carbamazepine (III) crystal-palmitic acid melt”. The study suggests a possible mechanism of the transformation of carbamazepine (III) into carbamazepine (II) on mechanical treatment with palmitic acid as an additive.

AB - Heating a single crystal of carbamazepine (III) (the thermodynamically stable form) in contact with solid palmitic acid resulted in the melting of palmitic acid and the growth of the crystals of carbamazepine (II) (the least stable polymorph) at the interface “carbamazepine (III) crystal-palmitic acid melt”. The study suggests a possible mechanism of the transformation of carbamazepine (III) into carbamazepine (II) on mechanical treatment with palmitic acid as an additive.

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85210303002&origin=inward&txGid=cd8187a7410abf9ee9cf4bffb5ea36ce

UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001363268200001

UR - https://www.mendeley.com/catalogue/db8749a2-0d5f-3cd9-89c6-acd981c53b6b/

U2 - 10.1039/d4ce00906a

DO - 10.1039/d4ce00906a

M3 - Article

VL - 26

SP - 6796

EP - 6804

JO - CrystEngComm

JF - CrystEngComm

SN - 1466-8033

IS - 48

ER -