Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Synthesis of N-heterocyclic amides based on (+)-camphoric acid and study of their antiviral activity and pharmacokinetics. / Yarovaya, O I; Baranova, D V; Sokolova, A S и др.
в: Russian Chemical Bulletin, Том 72, № 3, 03.2023, стр. 807-818.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Synthesis of N-heterocyclic amides based on (+)-camphoric acid and study of their antiviral activity and pharmacokinetics
AU - Yarovaya, O I
AU - Baranova, D V
AU - Sokolova, A S
AU - Nemolochnova, A G
AU - Sal'nikova, O P
AU - Fat'anova, A V
AU - Rogachev, A D
AU - Volobueva, A S
AU - Zarubaev, V V
AU - Pokrovsky, A G
AU - Salakhutdinov, N F
N1 - This work fi nancially supported by the Ministry of Science and Higher Education of the Russian Federation (Projects Nos FWUE-2022-0007, 122040400033-9; N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry (Siberian Branch of the Russian Academy of Sciences)). Biological assays toward infl uenza virus were carried out in terms of state assignment of the Pasteur Institute of Epidemiology and Microbiology (St. Petersburg, Russia) (Project No. AAAA-A21-121030200272-6). © Springer Science+Business Media LLC 2023.
PY - 2023/3
Y1 - 2023/3
N2 - Efficient conditions for the synthesis of nitrogen-containing heterocyclic derivatives of (1R,3S)(+)-camphoric acid were selected. A series of heterocyclic compounds based on (+)-camphoric acid bearing pharmacophoric fragments was synthesized using the developed methodology. The compounds were tested for their antiviral activity against SARS-CoV-2 and H1N1 influenza viruses, and efficient inhibitors were identified that are of significant interest for further studies. The stability of the compounds and pharmaco-kinetics of the leader compound were studied when administered intragastrically and intramuscularly to mice at a dose of 200 mg kg-1 using the HPLC-MS/MS method.
AB - Efficient conditions for the synthesis of nitrogen-containing heterocyclic derivatives of (1R,3S)(+)-camphoric acid were selected. A series of heterocyclic compounds based on (+)-camphoric acid bearing pharmacophoric fragments was synthesized using the developed methodology. The compounds were tested for their antiviral activity against SARS-CoV-2 and H1N1 influenza viruses, and efficient inhibitors were identified that are of significant interest for further studies. The stability of the compounds and pharmaco-kinetics of the leader compound were studied when administered intragastrically and intramuscularly to mice at a dose of 200 mg kg-1 using the HPLC-MS/MS method.
KW - (+)-camphoric acid
KW - A H1N1 influenza virus
KW - N-heterocycles
KW - SARS-CoV-2 virus
KW - pharmacokinetics
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85153255240&origin=inward&txGid=429f12c445eb1bdf69c936229f4d4e4e
UR - https://www.mendeley.com/catalogue/63f67054-12c2-31d5-a4ed-d800b46c0a54/
U2 - 10.1007/s11172-023-3845-9
DO - 10.1007/s11172-023-3845-9
M3 - Article
C2 - 37089866
VL - 72
SP - 807
EP - 818
JO - Russian Chemical Bulletin
JF - Russian Chemical Bulletin
SN - 1066-5285
IS - 3
ER -
ID: 48739858