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Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity. / Shchegravina, E S; Usova, S D; Baev, D S и др.

в: Russian Chemical Bulletin, Том 72, № 1, 01.01.2023, стр. 248-262.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Shchegravina, ES, Usova, SD, Baev, DS, Mozhaitsev, ES, Shcherbakov, DN, Belenkaya, SV, Volosnikova, EA, Chirkova, VY, Sharlaeva, EA, Svirshchevskaya, EV, Fonareva, IP, Sitdikova, AR, Salakhutdinov, NF, Yarovaya, OI & Fedorov, AY 2023, 'Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity', Russian Chemical Bulletin, Том. 72, № 1, стр. 248-262. https://doi.org/10.1007/s11172-023-3730-4

APA

Shchegravina, E. S., Usova, S. D., Baev, D. S., Mozhaitsev, E. S., Shcherbakov, D. N., Belenkaya, S. V., Volosnikova, E. A., Chirkova, V. Y., Sharlaeva, E. A., Svirshchevskaya, E. V., Fonareva, I. P., Sitdikova, A. R., Salakhutdinov, N. F., Yarovaya, O. I., & Fedorov, A. Y. (2023). Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity. Russian Chemical Bulletin, 72(1), 248-262. https://doi.org/10.1007/s11172-023-3730-4

Vancouver

Shchegravina ES, Usova SD, Baev DS, Mozhaitsev ES, Shcherbakov DN, Belenkaya SV и др. Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity. Russian Chemical Bulletin. 2023 янв. 1;72(1):248-262. doi: 10.1007/s11172-023-3730-4

Author

Shchegravina, E S ; Usova, S D ; Baev, D S и др. / Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity. в: Russian Chemical Bulletin. 2023 ; Том 72, № 1. стр. 248-262.

BibTeX

@article{786e8863149c4db0810a4c96c1176bf1,
title = "Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity",
abstract = "Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.",
keywords = "SARS-Cov-2 3CLPro, antiproliferative activity, colchicine, molecular docking, monoterpenoids",
author = "Shchegravina, {E S} and Usova, {S D} and Baev, {D S} and Mozhaitsev, {E S} and Shcherbakov, {D N} and Belenkaya, {S V} and Volosnikova, {E A} and Chirkova, {V Yu} and Sharlaeva, {E A} and Svirshchevskaya, {E V} and Fonareva, {I P} and Sitdikova, {A R} and Salakhutdinov, {N F} and Yarovaya, {O I} and Fedorov, {A Yu}",
note = "Synthesis of all compounds and biological studies were fi nancially supported by the Russian Science Foundation (Project No. 19-13-00158). Molecular docking was carried out with the fi nancial support from the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2021-1355 of October 12, 2021) in the framework of the implementation of selected activities of the Federal Scientifi c and Technical Program for the Development of Synchrotron and Neutron Research and Research Infrastructure for 2019—2027 years. {\textcopyright} Springer Science+Business Media LLC 2023.",
year = "2023",
month = jan,
day = "1",
doi = "10.1007/s11172-023-3730-4",
language = "English",
volume = "72",
pages = "248--262",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer Nature",
number = "1",

}

RIS

TY - JOUR

T1 - Synthesis of conjugates of (aR,7S)-colchicine with monoterpenoids and investigation of their biological activity

AU - Shchegravina, E S

AU - Usova, S D

AU - Baev, D S

AU - Mozhaitsev, E S

AU - Shcherbakov, D N

AU - Belenkaya, S V

AU - Volosnikova, E A

AU - Chirkova, V Yu

AU - Sharlaeva, E A

AU - Svirshchevskaya, E V

AU - Fonareva, I P

AU - Sitdikova, A R

AU - Salakhutdinov, N F

AU - Yarovaya, O I

AU - Fedorov, A Yu

N1 - Synthesis of all compounds and biological studies were fi nancially supported by the Russian Science Foundation (Project No. 19-13-00158). Molecular docking was carried out with the fi nancial support from the Ministry of Science and Higher Education of the Russian Federation (Agreement No. 075-15-2021-1355 of October 12, 2021) in the framework of the implementation of selected activities of the Federal Scientifi c and Technical Program for the Development of Synchrotron and Neutron Research and Research Infrastructure for 2019—2027 years. © Springer Science+Business Media LLC 2023.

PY - 2023/1/1

Y1 - 2023/1/1

N2 - Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.

AB - Conjugates of the natural alkaloid (aR,7S)-colchicine with bicyclic monoterpenoids and their derivatives were synthesized for the first time. Molecular docking of the synthesized agents in the active site of the main viral protease of the SARS-CoV-2 virus was carried out. The cytotoxic properties of the agents against different cell lines and the ability to inhibit the main viral protease 3CLPro were studied.

KW - SARS-Cov-2 3CLPro

KW - antiproliferative activity

KW - colchicine

KW - molecular docking

KW - monoterpenoids

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85148438386&origin=inward&txGid=f369d0f5202f6f538c7eb8edbfee1353

UR - https://www.mendeley.com/catalogue/672f9733-ebc5-37d3-91f2-3951c1ea25d9/

U2 - 10.1007/s11172-023-3730-4

DO - 10.1007/s11172-023-3730-4

M3 - Article

C2 - 36817557

VL - 72

SP - 248

EP - 262

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 1

ER -

ID: 44571830