TY - JOUR

T1 - Synthesis and Structures of Ferrocenylmethyl Leucine and a Copper(II) Complex Based on it

AU - Ermakova, E. A.

AU - Golubeva, Yu A.

AU - Smirnova, K. S.

AU - Klyushova, L. S.

AU - Savinykh, P. E.

AU - Eltsov, I. V.

AU - Lider, E. V.

N1 - The work was supported by the Russian Science Foundation (agreement No. 24-23-20148, 12.04.2024) and the Government of the Novosibirsk Oblast’, Russian Federation (agreement No. p-93, 22.03.2024), project No. 24-23-20148. Experiments on the analysis of cytotoxicity were performed using the facilities of the Multiple-Access Proteomic Analysis Center at the Federal Research Center of Fundamental and Translational Medicine and supported by the Ministry of Science of Higher Education of the Russian Federation, project No. 122032200236-1. Studies at the Multi-Access Center of the Nikolaev Institute of Inorganic Chemistry, Siberian Branch, Russian Academy of Sciences were supported by the Ministry of Science of Higher Education of the Russian Federation, project No. 121031700321-3. Synthesis and Structures of Ferrocenylmethyl Leucine and a Copper(II) Complex Based on it / E. A. Ermakova, Yu. A. Golubeva, K. S. Smirnova [et al.] // Journal of Structural Chemistry. – 2025. – Vol. 66, No. 4. – P. 702-711. – DOI 10.1134/S0022476625040067.

PY - 2025/5/7

Y1 - 2025/5/7

N2 - Abstract: Ferrocenylmethyl leucine (HL) and a copper(II) complex based on it [Cu(MeOH)LCl]n·nH2O (1) are obtained for the first time. The compounds are characterized by the elemental analysis, powder X-ray diffraction, and IR spectroscopy. The ligand structure is confirmed by NMR spectroscopy, and the structure of [Cu(MeOH)LCl]n complex (1a) is determined by the single crystal X-ray diffraction analysis. The complex obtained is a polymeric chain due to the chelate-bridging function of tetradentate L– coordinated by oxygen atoms of the carboxylate group and the nitrogen atom of the amino group. The stability of complex 1 is studied in methanol and an aqueous solution for 48 h. Cytotoxicity of the HL ligand and the copper(II) complex is investigated against MCF7 (breast adenocarcinoma) and MRC5 (lung fibroblast) cell lines. The complex is shown to exhibit the cytostatic activity in the concentration range of 5-50 µM against both cell lines.

AB - Abstract: Ferrocenylmethyl leucine (HL) and a copper(II) complex based on it [Cu(MeOH)LCl]n·nH2O (1) are obtained for the first time. The compounds are characterized by the elemental analysis, powder X-ray diffraction, and IR spectroscopy. The ligand structure is confirmed by NMR spectroscopy, and the structure of [Cu(MeOH)LCl]n complex (1a) is determined by the single crystal X-ray diffraction analysis. The complex obtained is a polymeric chain due to the chelate-bridging function of tetradentate L– coordinated by oxygen atoms of the carboxylate group and the nitrogen atom of the amino group. The stability of complex 1 is studied in methanol and an aqueous solution for 48 h. Cytotoxicity of the HL ligand and the copper(II) complex is investigated against MCF7 (breast adenocarcinoma) and MRC5 (lung fibroblast) cell lines. The complex is shown to exhibit the cytostatic activity in the concentration range of 5-50 µM against both cell lines.

KW - copper(II) complex

KW - crystal structure

KW - cytotoxicity

KW - ferrocene

UR - https://www.mendeley.com/catalogue/039b5229-8c6b-30e2-a833-ffd99ac0d84d/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-105004445994&origin=inward&txGid=a1ad57343e2ef6d425621d2391698734

UR - https://elibrary.ru/item.asp?id=82272584

U2 - 10.1134/S0022476625040067

DO - 10.1134/S0022476625040067

M3 - Article

VL - 66

SP - 702

EP - 711

JO - Journal of Structural Chemistry

JF - Journal of Structural Chemistry

SN - 0022-4766

IS - 4

ER -