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Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus. / Sokolova, A. S.; Yarovaya, O. I.; Semenova, M. D. и др.

в: MedChemComm, Том 8, № 5, 01.05.2017, стр. 960-963.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Sokolova, AS, Yarovaya, OI, Semenova, MD, Shtro, AA, Orshanskaya, IR, Zarubaev, VV & Salakhutdinov, NF 2017, 'Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus', MedChemComm, Том. 8, № 5, стр. 960-963. https://doi.org/10.1039/c6md00657d

APA

Sokolova, A. S., Yarovaya, O. I., Semenova, M. D., Shtro, A. A., Orshanskaya, I. R., Zarubaev, V. V., & Salakhutdinov, N. F. (2017). Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus. MedChemComm, 8(5), 960-963. https://doi.org/10.1039/c6md00657d

Vancouver

Sokolova AS, Yarovaya OI, Semenova MD, Shtro AA, Orshanskaya IR, Zarubaev VV и др. Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus. MedChemComm. 2017 май 1;8(5):960-963. doi: 10.1039/c6md00657d

Author

Sokolova, A. S. ; Yarovaya, O. I. ; Semenova, M. D. и др. / Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus. в: MedChemComm. 2017 ; Том 8, № 5. стр. 960-963.

BibTeX

@article{003a5ea324464a148620d21e1a604467,
title = "Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus",
abstract = "Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (-)-borneol and (-)-isoborneol as potent inhibitors of the influenza A virus. All compounds were tested for their toxicity against MDCK cells and for virus-inhibiting activity against the influenza virus A/Puerto Rico/8/34 (H1N1). Compounds 7, 16 and 26 containing a morpholine fragment exhibited the highest efficiency as agents inhibiting the replication of the influenza virus A(H1N1) with selectivity indices of 82, 45 and 65, correspondingly. Derivatives 9 (SI = 23) and 18 (SI = 25) containing a 1-methylpiperazine motif showed moderate antiviral activity. Structure-activity analysis of this new series of borneol derivatives revealed that a 1,7,7-trimethylbicyclo[2.2.1]heptan scaffold is required for the antiviral activity.",
keywords = "CHANNEL, DISCOVERY, OSELTAMIVIR-RESISTANT INFLUENZA, UNITED-STATES, VIVO",
author = "Sokolova, {A. S.} and Yarovaya, {O. I.} and Semenova, {M. D.} and Shtro, {A. A.} and Orshanskaya, {I. R.} and Zarubaev, {V. V.} and Salakhutdinov, {N. F.}",
year = "2017",
month = may,
day = "1",
doi = "10.1039/c6md00657d",
language = "English",
volume = "8",
pages = "960--963",
journal = "MedChemComm",
issn = "2040-2503",
publisher = "Royal Society of Chemistry",
number = "5",

}

RIS

TY - JOUR

T1 - Synthesis and in vitro study of novel borneol derivatives as potent inhibitors of the influenza A virus

AU - Sokolova, A. S.

AU - Yarovaya, O. I.

AU - Semenova, M. D.

AU - Shtro, A. A.

AU - Orshanskaya, I. R.

AU - Zarubaev, V. V.

AU - Salakhutdinov, N. F.

PY - 2017/5/1

Y1 - 2017/5/1

N2 - Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (-)-borneol and (-)-isoborneol as potent inhibitors of the influenza A virus. All compounds were tested for their toxicity against MDCK cells and for virus-inhibiting activity against the influenza virus A/Puerto Rico/8/34 (H1N1). Compounds 7, 16 and 26 containing a morpholine fragment exhibited the highest efficiency as agents inhibiting the replication of the influenza virus A(H1N1) with selectivity indices of 82, 45 and 65, correspondingly. Derivatives 9 (SI = 23) and 18 (SI = 25) containing a 1-methylpiperazine motif showed moderate antiviral activity. Structure-activity analysis of this new series of borneol derivatives revealed that a 1,7,7-trimethylbicyclo[2.2.1]heptan scaffold is required for the antiviral activity.

AB - Herein, we present the design and synthesis of a series of novel heterocyclic derivatives of (-)-borneol and (-)-isoborneol as potent inhibitors of the influenza A virus. All compounds were tested for their toxicity against MDCK cells and for virus-inhibiting activity against the influenza virus A/Puerto Rico/8/34 (H1N1). Compounds 7, 16 and 26 containing a morpholine fragment exhibited the highest efficiency as agents inhibiting the replication of the influenza virus A(H1N1) with selectivity indices of 82, 45 and 65, correspondingly. Derivatives 9 (SI = 23) and 18 (SI = 25) containing a 1-methylpiperazine motif showed moderate antiviral activity. Structure-activity analysis of this new series of borneol derivatives revealed that a 1,7,7-trimethylbicyclo[2.2.1]heptan scaffold is required for the antiviral activity.

KW - CHANNEL

KW - DISCOVERY

KW - OSELTAMIVIR-RESISTANT INFLUENZA

KW - UNITED-STATES

KW - VIVO

UR - http://www.scopus.com/inward/record.url?scp=85021957010&partnerID=8YFLogxK

U2 - 10.1039/c6md00657d

DO - 10.1039/c6md00657d

M3 - Article

C2 - 30108810

AN - SCOPUS:85021957010

VL - 8

SP - 960

EP - 963

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 5

ER -

ID: 9561058