TY - JOUR

T1 - Synthesis and antiviral activity of camphor-based 1,3-thiazolidin-4-one and thiazole derivatives as Orthopoxvirus-reproduction inhibitors

AU - Sokolova, Anastasiya S.

AU - Yarovaya, Olga I.

AU - Bormotov, Nikolay I.

AU - Shishkina, Larisa N.

AU - Salakhutdinov, Nariman F.

N1 - Publisher Copyright: © The Royal Society of Chemistry.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - The Orthopoxvirus genus belongs to the Poxviridae family and includes variola virus (smallpox), cowpox virus, monkeypox virus and vaccinia virus (VV). Smallpox is considered one of the great epidemic disease scourges in human history. It has currently been eradicated; however, it remains a considerable threat as a biowarfare or bioterrorist weapon. The poxvirus, VV, serves as a model virus from which new antiviral therapies against Orthopoxviruses can be identified. Here, a series of nitrogen-sulphur containing heterocycles such as 1,3-thiazolidin-4-one and thiazoles containing a 1,7,7-trimethylbicyclo[2.2.1]heptan scaffold were synthesized and screened for their antiviral activity. The bioassay results showed that the 4b, 4c and 4e thiazoles, which contained a substituted benzene ring, were able to inhibit VV reproduction with IC50 values in the 2.4-3.7 micromolar range whilst exhibiting moderate cytotoxicity. Among the thiazolidin-4-one derivatives, compound 8b, which contained a 4-methylbenzylidene group, displayed good inhibitory activity (IC50 = 9.5 μM) and moderate toxicity.

AB - The Orthopoxvirus genus belongs to the Poxviridae family and includes variola virus (smallpox), cowpox virus, monkeypox virus and vaccinia virus (VV). Smallpox is considered one of the great epidemic disease scourges in human history. It has currently been eradicated; however, it remains a considerable threat as a biowarfare or bioterrorist weapon. The poxvirus, VV, serves as a model virus from which new antiviral therapies against Orthopoxviruses can be identified. Here, a series of nitrogen-sulphur containing heterocycles such as 1,3-thiazolidin-4-one and thiazoles containing a 1,7,7-trimethylbicyclo[2.2.1]heptan scaffold were synthesized and screened for their antiviral activity. The bioassay results showed that the 4b, 4c and 4e thiazoles, which contained a substituted benzene ring, were able to inhibit VV reproduction with IC50 values in the 2.4-3.7 micromolar range whilst exhibiting moderate cytotoxicity. Among the thiazolidin-4-one derivatives, compound 8b, which contained a 4-methylbenzylidene group, displayed good inhibitory activity (IC50 = 9.5 μM) and moderate toxicity.

KW - EFFICACY

KW - IN-VITRO

KW - THIOSEMICARBAZONES

UR - http://www.scopus.com/inward/record.url?scp=85055253938&partnerID=8YFLogxK

U2 - 10.1039/C8MD00347E

DO - 10.1039/C8MD00347E

M3 - Article

C2 - 30429979

AN - SCOPUS:85055253938

VL - 9

SP - 1746

EP - 1753

JO - MedChemComm

JF - MedChemComm

SN - 2040-2503

IS - 10

ER -