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Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety. / Mironov, M. E.; Poltanovich, A. I.; Rybalova, T. V. и др.

в: Russian Chemical Bulletin, Том 69, № 3, 03.2020, стр. 537-546.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Mironov, ME, Poltanovich, AI, Rybalova, TV, Dolgikh, MP, Tolstikova, TG & Shults, EE 2020, 'Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety', Russian Chemical Bulletin, Том. 69, № 3, стр. 537-546. https://doi.org/10.1007/s11172-020-2795-6

APA

Mironov, M. E., Poltanovich, A. I., Rybalova, T. V., Dolgikh, M. P., Tolstikova, T. G., & Shults, E. E. (2020). Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety. Russian Chemical Bulletin, 69(3), 537-546. https://doi.org/10.1007/s11172-020-2795-6

Vancouver

Mironov ME, Poltanovich AI, Rybalova TV, Dolgikh MP, Tolstikova TG, Shults EE. Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety. Russian Chemical Bulletin. 2020 март;69(3):537-546. doi: 10.1007/s11172-020-2795-6

Author

Mironov, M. E. ; Poltanovich, A. I. ; Rybalova, T. V. и др. / Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety. в: Russian Chemical Bulletin. 2020 ; Том 69, № 3. стр. 537-546.

BibTeX

@article{8aed000db9d044b1ad2271fe3cd7206f,
title = "Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety",
abstract = "Conjugates of terpenoids with 1,3,5-trisubstituted pyrazoles were synthesized by the cross-coupling of methyl 16-(2-chloro-2-oxoacetyl)labdatrienoate with terminal arylacetylenes via the Castro—Stephens reaction and heterocyclization of arylalkyne-1,2-diones with arylhydr-azines. The structure of one reaction product was established by X-ray diffraction. The conditions for the formation of furanolabdanoid arylalkyne-1,2-diones were found. The newly synthesized pyrazoles exhibit analgesic activity in a model of chemical irritation.",
keywords = "alkyne-1,2-diones, Castro—Stephens cross-coupling, diterpenoids, furanolabdanoids, heterocyclization, phenyl-hydrazines, phlomisoic acid, pyrazoles, X-ray diffraction, SERIES, YNEDIONES, CRYSTAL-STRUCTURES, ALPHA, FURANODITERPENOIDS, alkyne-1, ACETYLENIC KETONES, LAMBERTIANIC ACID, DERIVATIVES, 2-diones, TRANSFORMATIONS, Castro-Stephens cross-coupling",
author = "Mironov, {M. E.} and Poltanovich, {A. I.} and Rybalova, {T. V.} and Dolgikh, {M. P.} and Tolstikova, {T. G.} and Shults, {E. E.}",
year = "2020",
month = mar,
doi = "10.1007/s11172-020-2795-6",
language = "English",
volume = "69",
pages = "537--546",
journal = "Russian Chemical Bulletin",
issn = "1066-5285",
publisher = "Springer Nature",
number = "3",

}

RIS

TY - JOUR

T1 - Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety

AU - Mironov, M. E.

AU - Poltanovich, A. I.

AU - Rybalova, T. V.

AU - Dolgikh, M. P.

AU - Tolstikova, T. G.

AU - Shults, E. E.

PY - 2020/3

Y1 - 2020/3

N2 - Conjugates of terpenoids with 1,3,5-trisubstituted pyrazoles were synthesized by the cross-coupling of methyl 16-(2-chloro-2-oxoacetyl)labdatrienoate with terminal arylacetylenes via the Castro—Stephens reaction and heterocyclization of arylalkyne-1,2-diones with arylhydr-azines. The structure of one reaction product was established by X-ray diffraction. The conditions for the formation of furanolabdanoid arylalkyne-1,2-diones were found. The newly synthesized pyrazoles exhibit analgesic activity in a model of chemical irritation.

AB - Conjugates of terpenoids with 1,3,5-trisubstituted pyrazoles were synthesized by the cross-coupling of methyl 16-(2-chloro-2-oxoacetyl)labdatrienoate with terminal arylacetylenes via the Castro—Stephens reaction and heterocyclization of arylalkyne-1,2-diones with arylhydr-azines. The structure of one reaction product was established by X-ray diffraction. The conditions for the formation of furanolabdanoid arylalkyne-1,2-diones were found. The newly synthesized pyrazoles exhibit analgesic activity in a model of chemical irritation.

KW - alkyne-1,2-diones

KW - Castro—Stephens cross-coupling

KW - diterpenoids

KW - furanolabdanoids

KW - heterocyclization

KW - phenyl-hydrazines

KW - phlomisoic acid

KW - pyrazoles

KW - X-ray diffraction

KW - SERIES

KW - YNEDIONES

KW - CRYSTAL-STRUCTURES

KW - ALPHA

KW - FURANODITERPENOIDS

KW - alkyne-1

KW - ACETYLENIC KETONES

KW - LAMBERTIANIC ACID

KW - DERIVATIVES

KW - 2-diones

KW - TRANSFORMATIONS

KW - Castro-Stephens cross-coupling

UR - http://www.scopus.com/inward/record.url?scp=85083298965&partnerID=8YFLogxK

U2 - 10.1007/s11172-020-2795-6

DO - 10.1007/s11172-020-2795-6

M3 - Article

AN - SCOPUS:85083298965

VL - 69

SP - 537

EP - 546

JO - Russian Chemical Bulletin

JF - Russian Chemical Bulletin

SN - 1066-5285

IS - 3

ER -

ID: 24076412