TY - JOUR

T1 - Subcellular compartmentalization of the plant antioxidant system

T2 - an integrated overview

AU - Bobrovskikh, Aleksandr

AU - Zubairova, Ulyana

AU - Kolodkin, Alexey

AU - Doroshkov, Alexey

N1 - Publisher Copyright: © Copyright 2020 Bobrovskikh et al. Copyright: Copyright 2021 Elsevier B.V., All rights reserved.

PY - 2020/7/16

Y1 - 2020/7/16

N2 - The antioxidant system (AOS) maintains the optimal concentration of reactive oxygen species (ROS) in a cell and protects it against oxidative stress. In plants, the AOS consists of seven main classes of antioxidant enzymes, low-molecular antioxidants (e.g., ascorbate, glutathione, and their oxidized forms) and thioredoxin/glutaredoxin systems which can serve as reducing agents for antioxidant enzymes. The number of genes encoding AOS enzymes varies between classes, and same class enzymes encoded by different gene copies may have different subcellular localizations, functional loads and modes of evolution. These facts hereafter reinforce the complex nature of AOS regulation and functioning. Further studies can describe new trends in the behavior and functioning of systems components, and provide new fundamental knowledge about systems regulation. The system is revealed to have a lot of interactions and interplay pathways between its components at the subcellular level (antioxidants, enzymes, ROS level, and hormonal and transcriptional regulation). These facts should be taken into account in further studies during the AOS modeling by describing the main pathways of generating and utilizing ROS, as well as the associated signaling processes and regulation of the system on cellular and organelle levels, which is a complicated and ambitious task Another objective for studying the phenomenon of the AOS is related to the influence of cell dynamics and circadian rhythms on it. Therefore, the AOS requires an integrated and multi-level approach to study. We focused this review on the existing scientific background and experimental data used for the systems biology research of the plant AOS.

AB - The antioxidant system (AOS) maintains the optimal concentration of reactive oxygen species (ROS) in a cell and protects it against oxidative stress. In plants, the AOS consists of seven main classes of antioxidant enzymes, low-molecular antioxidants (e.g., ascorbate, glutathione, and their oxidized forms) and thioredoxin/glutaredoxin systems which can serve as reducing agents for antioxidant enzymes. The number of genes encoding AOS enzymes varies between classes, and same class enzymes encoded by different gene copies may have different subcellular localizations, functional loads and modes of evolution. These facts hereafter reinforce the complex nature of AOS regulation and functioning. Further studies can describe new trends in the behavior and functioning of systems components, and provide new fundamental knowledge about systems regulation. The system is revealed to have a lot of interactions and interplay pathways between its components at the subcellular level (antioxidants, enzymes, ROS level, and hormonal and transcriptional regulation). These facts should be taken into account in further studies during the AOS modeling by describing the main pathways of generating and utilizing ROS, as well as the associated signaling processes and regulation of the system on cellular and organelle levels, which is a complicated and ambitious task Another objective for studying the phenomenon of the AOS is related to the influence of cell dynamics and circadian rhythms on it. Therefore, the AOS requires an integrated and multi-level approach to study. We focused this review on the existing scientific background and experimental data used for the systems biology research of the plant AOS.

KW - Antioxidant system

KW - Reactive oxygen species

KW - Antioxidants

KW - Systems biology

KW - Plant cell

KW - Compartments

KW - Mathematical modeling

KW - OXIDATIVE STRESS

KW - ASCORBATE PEROXIDASE

KW - REACTIVE OXYGEN

KW - HYDROGEN-PEROXIDE

KW - SALT-TOLERANT

KW - GLUTATHIONE PEROXIDASES

KW - CULTIVATED TOMATO

KW - GENE-EXPRESSION

KW - DEHYDROASCORBATE REDUCTASE

KW - SUPEROXIDE DISMUTASES

UR - http://www.scopus.com/inward/record.url?scp=85105185252&partnerID=8YFLogxK

U2 - 10.7717/peerj.9451

DO - 10.7717/peerj.9451

M3 - Review article

C2 - 32742779

VL - 8

SP - e9451

JO - PeerJ

JF - PeerJ

SN - 2167-8359

M1 - e9451

ER -