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Structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O and Synthesis of Pt(IV) Prodrugs Based on It. / Zazulya, A. E.; Abramov, P. A.; Tkachev, S. V. и др.
в: Journal of Structural Chemistry, Том 66, № 9, 09.10.2025, стр. 1820-1830.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O and Synthesis of Pt(IV) Prodrugs Based on It
AU - Zazulya, A. E.
AU - Abramov, P. A.
AU - Tkachev, S. V.
AU - Sheven’, D. G.
AU - Komarovskikh, A. Yu
AU - Plyusnin, P. E.
AU - Vasilchenko, D. B.
N1 - The work on the synthesis of trans,trans-[Pt(py)2(N3)2(OH)(SuccH)] and trans,trans-[Pt(py)2(N3)2(OH)(Succ-NH-TEMPO)] complexes were supported by the Russian Science Foundation (grant No. 23-13-00226). The structure study of dihydrate trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O was supported by the Ministry of Science and Higher Education of the Russian Federation (project No. 121031700315-2). Structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O and Synthesis of Pt(IV) Prodrugs Based on It / A. E. Zazulya, P. A. Abramov, S. V. Tkachev [et al.] // Journal of Structural Chemistry. – 2025. – Vol. 66, No. 9. – P. 1820-1830. – DOI 10.1134/S0022476625090057.
PY - 2025/10/9
Y1 - 2025/10/9
N2 - Abstract: The structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O is studied by single crystal X-ray diffraction. The crystallographic data are: a = 9.8240(2) Å, b = 17.2178(3) Å, c = 9.5248(2) Å, β = 97.777(1)°, space group P21/c, Z = 4, ρcal = 2.11 g/cm3. The crystal structure of the complex consists of molecular layers perpendicular to the c direction. The transformation process of the dehydrate to the anhydrous complex is analyzed by thermal gravimetry. The previously published synthesis procedures of trans,trans-[Pt(py)2(N3)2(OH)(SuccH)] and trans,trans-[Pt(py)2(N3)2(OH)(Succ-NH-TEMPO)] complexes from trans,trans-[Pt(py)2(N3)2(OH)2] are modified. The optimization of synthesis conditions and the product isolation procedure increases the product yield and substantially improves the purity of the obtained compounds.
AB - Abstract: The structure of trans,trans-[Pt(py)2(N3)2(OH)2]·2H2O is studied by single crystal X-ray diffraction. The crystallographic data are: a = 9.8240(2) Å, b = 17.2178(3) Å, c = 9.5248(2) Å, β = 97.777(1)°, space group P21/c, Z = 4, ρcal = 2.11 g/cm3. The crystal structure of the complex consists of molecular layers perpendicular to the c direction. The transformation process of the dehydrate to the anhydrous complex is analyzed by thermal gravimetry. The previously published synthesis procedures of trans,trans-[Pt(py)2(N3)2(OH)(SuccH)] and trans,trans-[Pt(py)2(N3)2(OH)(Succ-NH-TEMPO)] complexes from trans,trans-[Pt(py)2(N3)2(OH)2] are modified. The optimization of synthesis conditions and the product isolation procedure increases the product yield and substantially improves the purity of the obtained compounds.
KW - azide complexes
KW - nitroxyl radical
KW - platinum
KW - prodrugs
KW - single crystal X-ray diffraction analysis
KW - spectroscopy
UR - https://www.mendeley.com/catalogue/935cc300-90d5-399d-84c2-9977461de652/
UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105018610672&origin=inward
UR - https://www.elibrary.ru/item.asp?id=83009100
U2 - 10.1134/S0022476625090057
DO - 10.1134/S0022476625090057
M3 - Article
VL - 66
SP - 1820
EP - 1830
JO - Journal of Structural Chemistry
JF - Journal of Structural Chemistry
SN - 0022-4766
IS - 9
ER -
ID: 70967374