TY - JOUR

T1 - Strenght properties of abdominal aortic vessels: experimental results and perspectives

AU - Lipovka, A. I.

AU - Karpenko, A. A.

AU - Chupakhin, A. P.

AU - Parshin, D. V.

N1 - Funding Information: This work was supported by the Russian Science Foundation (Grant No. 21-15-00091). Publisher Copyright: © 2022, Pleiades Publishing, Ltd.

PY - 2022/4

Y1 - 2022/4

N2 - The aorta is the main vessel in the human circulatory system which plays a critical role in oxygen and nutrient supply to all abdominal organs and to the lower limbs. A critical pathology of this vessel is an aneurysm. An important problem in medical practice is to predict aortic aneurysm rupture and plan surgery since aneurysm rupture outside a hospital, as a rule, leads to a lethal outcome. To develop adequate mathematical models that predict such an outcome, it is necessary to determine the strength characteristics of tissues of the aorta, aortic aneurysm, and iliac arteries at various stages of aneurysm growth based on individual patient data. The strength characteristics of the tissues of the human aorta, aortic aneurysm, and common iliac arteries have been studied. It has been experimentally proved that in healthy aorta tissue specimens, the differences between the ultimate relative strains in the axial and circumferential directions are statistically significant (p=0.033), which is not observed in the case of the aortic aneurysm. The results can also be treated as remodeling of the aortic aneurysm wall compared to the healthy aorta. These data can be used to develop predictive models for aortic aneurysm rupture in personalized hydroelastic modeling.

AB - The aorta is the main vessel in the human circulatory system which plays a critical role in oxygen and nutrient supply to all abdominal organs and to the lower limbs. A critical pathology of this vessel is an aneurysm. An important problem in medical practice is to predict aortic aneurysm rupture and plan surgery since aneurysm rupture outside a hospital, as a rule, leads to a lethal outcome. To develop adequate mathematical models that predict such an outcome, it is necessary to determine the strength characteristics of tissues of the aorta, aortic aneurysm, and iliac arteries at various stages of aneurysm growth based on individual patient data. The strength characteristics of the tissues of the human aorta, aortic aneurysm, and common iliac arteries have been studied. It has been experimentally proved that in healthy aorta tissue specimens, the differences between the ultimate relative strains in the axial and circumferential directions are statistically significant (p=0.033), which is not observed in the case of the aortic aneurysm. The results can also be treated as remodeling of the aortic aneurysm wall compared to the healthy aorta. These data can be used to develop predictive models for aortic aneurysm rupture in personalized hydroelastic modeling.

KW - abdominal aortic aneurysm

KW - biomechanics

KW - hydroelasticity

KW - ultimate strength characteristics

KW - uniaxial mechanical test

UR - http://www.scopus.com/inward/record.url?scp=85133934369&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/20149647-04bd-36c4-a791-d183e2346062/

U2 - 10.1134/S0021894422020080

DO - 10.1134/S0021894422020080

M3 - Article

AN - SCOPUS:85133934369

VL - 63

SP - 251

EP - 258

JO - Journal of Applied Mechanics and Technical Physics

JF - Journal of Applied Mechanics and Technical Physics

SN - 0021-8944

IS - 2

ER -