TY - JOUR

T1 - Specifics of anaphase chromatid disjunction in Drosophila melanogaster mitotic mutants

AU - Lebedeva, L. I.

AU - Fedorova, S. A.

AU - Omel'ianchuk, L. V.

PY - 2008/8

Y1 - 2008/8

N2 - Anaphase chromatid behavior defects (CBDs) were quantitatively and qualitatively studied in nerve ganglion cells of third-instar larvae of several control wild-type Drosophila melanogaster strains and four strains with mutations of the aar(v158), ff3, mast(v40), and CycB(2g) cell-cycle genes. A linear specificity was observed for the CBD frequency, type, determination, and correction probability. The probability of anaphase CBD correction was close to unity in the control strains and lower in the mutant strains. The lower correction probability in the mutant strains was explained in the context of two findings, that the mutations induced the CBDs that were atypical of the wild-type strains and were potentially uncorrectable in anaphase and that the mutations negatively affected the relative anaphase time in mitosis.

AB - Anaphase chromatid behavior defects (CBDs) were quantitatively and qualitatively studied in nerve ganglion cells of third-instar larvae of several control wild-type Drosophila melanogaster strains and four strains with mutations of the aar(v158), ff3, mast(v40), and CycB(2g) cell-cycle genes. A linear specificity was observed for the CBD frequency, type, determination, and correction probability. The probability of anaphase CBD correction was close to unity in the control strains and lower in the mutant strains. The lower correction probability in the mutant strains was explained in the context of two findings, that the mutations induced the CBDs that were atypical of the wild-type strains and were potentially uncorrectable in anaphase and that the mutations negatively affected the relative anaphase time in mitosis.

UR - http://www.scopus.com/inward/record.url?scp=54549096044&partnerID=8YFLogxK

M3 - Article

C2 - 18825954

AN - SCOPUS:54549096044

VL - 44

SP - 1056

EP - 1065

JO - Генетика

JF - Генетика

SN - 0016-6758

IS - 8

ER -