TY - JOUR

T1 - Simple and efficient modifications of well known techniques for reliable growth of high-quality crystals of small bioorganic molecules

AU - Rychkov, Denis A.

AU - Arkhipov, Sergey G.

AU - Boldyreva, Elena V.

PY - 2014/8

Y1 - 2014/8

N2 - A number of modifications to traditional techniques are suggested in order to overcome problems that frequently arise when growing crystals from solution. These improvements, and their combination, help to avoid problems such as poor nucleation, the spontaneous precipitation of many poor-quality small powder-like crystals, crystals adhering to the crystallization vessel or to each other, and chemical degradation of the solution. The proposed techniques can be used to crystallize desirable metastable polymorphs reliably. None of the suggested methods demands the usage of any special or expensive equipment, or specific skills, and they can be implemented in the chemistry curriculum even at secondary school level. Examples are given for the crystallization of small organic molecules such as carboxylic acids, amino acids, pharmaceuticals etc., but the same techniques are applicable to other classes of compound.

AB - A number of modifications to traditional techniques are suggested in order to overcome problems that frequently arise when growing crystals from solution. These improvements, and their combination, help to avoid problems such as poor nucleation, the spontaneous precipitation of many poor-quality small powder-like crystals, crystals adhering to the crystallization vessel or to each other, and chemical degradation of the solution. The proposed techniques can be used to crystallize desirable metastable polymorphs reliably. None of the suggested methods demands the usage of any special or expensive equipment, or specific skills, and they can be implemented in the chemistry curriculum even at secondary school level. Examples are given for the crystallization of small organic molecules such as carboxylic acids, amino acids, pharmaceuticals etc., but the same techniques are applicable to other classes of compound.

KW - control of nucleation

KW - control of nuclei growth

KW - crystal growth from solution

KW - Raman spectroscopy

KW - seeding

KW - X-ray diffraction

UR - http://www.scopus.com/inward/record.url?scp=84905454410&partnerID=8YFLogxK

U2 - 10.1107/S1600576714011273

DO - 10.1107/S1600576714011273

M3 - Article

AN - SCOPUS:84905454410

VL - 47

SP - 1435

EP - 1442

JO - Journal of Applied Crystallography

JF - Journal of Applied Crystallography

SN - 0021-8898

IS - 4

ER -