TY - JOUR

T1 - Similarities and differences among the Opisthorchiidae liver flukes: Insights from Opisthorchis felineus

AU - Pakharukova, Maria Y.

AU - Mordvinov, Viatcheslav A.

N1 - Publisher Copyright: © 2022 Cambridge University Press. All rights reserved.

PY - 2022/9/16

Y1 - 2022/9/16

N2 - The foodborne liver trematode Opisthorchis felineus (Rivolta, 1884) is a member of the triad of phylogenetically related epidemiologically important Opisthorchiidae trematodes, which also includes O. viverrini (Poirier, 1886) and Clonorchis sinensis (Loos, 1907). Despite similarity in the life cycle, Opisthorchiidae liver flukes also have marked differences. Two species (O. viverrini and C. sinensis) are recognized as Group 1A biological carcinogens, whereas O. felineus belongs to Group 3A. In this review, we focus on these questions: Are there actual differences in carcinogenicity among these 3 liver fluke species? Is there an explanation for these differences? We provide a recent update of our knowledge on the liver fluke O. felineus and highlight its differences from O. viverrini and C. sinensis. In particular, we concentrate on differences in the climate of endemic areas, characteristics of the life cycle, the range of intermediate hosts, genomic and transcriptomic features of the pathogens, and clinical symptoms and morbidity of the infections in humans. The discussion of these questions can stimulate new developments in comparative studies on the pathogenicity of liver flukes and should help to identify species-specific features of opisthorchiasis and clonorchiasis pathogenesis.

AB - The foodborne liver trematode Opisthorchis felineus (Rivolta, 1884) is a member of the triad of phylogenetically related epidemiologically important Opisthorchiidae trematodes, which also includes O. viverrini (Poirier, 1886) and Clonorchis sinensis (Loos, 1907). Despite similarity in the life cycle, Opisthorchiidae liver flukes also have marked differences. Two species (O. viverrini and C. sinensis) are recognized as Group 1A biological carcinogens, whereas O. felineus belongs to Group 3A. In this review, we focus on these questions: Are there actual differences in carcinogenicity among these 3 liver fluke species? Is there an explanation for these differences? We provide a recent update of our knowledge on the liver fluke O. felineus and highlight its differences from O. viverrini and C. sinensis. In particular, we concentrate on differences in the climate of endemic areas, characteristics of the life cycle, the range of intermediate hosts, genomic and transcriptomic features of the pathogens, and clinical symptoms and morbidity of the infections in humans. The discussion of these questions can stimulate new developments in comparative studies on the pathogenicity of liver flukes and should help to identify species-specific features of opisthorchiasis and clonorchiasis pathogenesis.

KW - cholangiocarcinoma

KW - foodborne trematodes

KW - liver flukes

KW - Opisthorchis felineus

KW - Humans

KW - Clonorchiasis

KW - Opisthorchiasis/epidemiology

KW - Life Cycle Stages

KW - Fasciola hepatica

KW - Opisthorchis/genetics

KW - Animals

KW - Clonorchis sinensis/genetics

KW - Fascioliasis

KW - Cholangiocarcinoma

UR - http://www.scopus.com/inward/record.url?scp=85130550150&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/a2c786d2-8832-343a-9026-978edad2e17b/

U2 - 10.1017/S0031182022000397

DO - 10.1017/S0031182022000397

M3 - Review article

C2 - 35570685

AN - SCOPUS:85130550150

VL - 149

SP - 1306

EP - 1318

JO - Parasitology

JF - Parasitology

SN - 0031-1820

IS - 10

ER -