TY - JOUR

T1 - Sex difference feeding behaviour of NOD SCID mice in a pharmacological model of type 1 diabetes

AU - Tur, Daria A.

AU - Khotskin, Nikita V.

AU - Akulov, Andrey E.

N1 - Funding Information: The study was undertaken using a grant from the Russian Foundation for Basic Research (Project No. 19-315-90008). The maintenance of the genetic line of NOD SCID mice and diabetic modelling was performed at the expense of state order No. 0259-2019-0004-C-01. Publisher Copyright: © 2021 Wiley-VCH GmbH

PY - 2021/9

Y1 - 2021/9

N2 - This study aimed to assess the sex differences in the feeding behaviour of non-obese diabetic severe combined immunodeficient (NOD SCID) mice in a pharmacological model of type 1 diabetes mellitus (T1Dm). In our study, we chose NOD SCID mice of both sexes and assessed their feeding behaviour, body weight, body fat and water content under identical experimental conditions and diets. After 1 month of diabetes mellitus in mice in the experimental group, males and females did not show any increase in body weight, and they weighed significantly less than the control group. However, compared with the control group, in females with a background of T1Dm, there was a significant decrease in body fat. The amount of water consumed in the experimental groups was higher than that in the control groups. The amount of food consumed by males increased when they increased their water consumption, whereas food consumption in females decreased significantly with an increase in water consumption. Thus, we discovered sex differences in the feeding behaviour, body weight and body fat and water content in the pharmacological model of T1Dm after 1 month in NOD SCID mice.

AB - This study aimed to assess the sex differences in the feeding behaviour of non-obese diabetic severe combined immunodeficient (NOD SCID) mice in a pharmacological model of type 1 diabetes mellitus (T1Dm). In our study, we chose NOD SCID mice of both sexes and assessed their feeding behaviour, body weight, body fat and water content under identical experimental conditions and diets. After 1 month of diabetes mellitus in mice in the experimental group, males and females did not show any increase in body weight, and they weighed significantly less than the control group. However, compared with the control group, in females with a background of T1Dm, there was a significant decrease in body fat. The amount of water consumed in the experimental groups was higher than that in the control groups. The amount of food consumed by males increased when they increased their water consumption, whereas food consumption in females decreased significantly with an increase in water consumption. Thus, we discovered sex differences in the feeding behaviour, body weight and body fat and water content in the pharmacological model of T1Dm after 1 month in NOD SCID mice.

KW - body fat

KW - body weight

KW - feeding behaviour

KW - mice

KW - type 1 diabetes

UR - http://www.scopus.com/inward/record.url?scp=85101864937&partnerID=8YFLogxK

U2 - 10.1111/jpn.13517

DO - 10.1111/jpn.13517

M3 - Article

C2 - 33655640

AN - SCOPUS:85101864937

VL - 105

SP - 984

EP - 988

JO - Journal of Animal Physiology and Animal Nutrition

JF - Journal of Animal Physiology and Animal Nutrition

SN - 0931-2439

IS - 5

ER -