TY - JOUR

T1 - Sex- and Strain-Related Differences in the Extinction of a Conditioned Passive Avoidance Reaction in DISC-L100P and C57BL/6 Mice

AU - Chizhova, N. D.

AU - Smirnova, K. V.

AU - Dubrovina, N. I.

AU - Lipina, T. V.

AU - Amstislavskaya, T. G.

N1 - Публикация для корректировки.

PY - 2023/10

Y1 - 2023/10

N2 - We report here studies of sex-related and interstrain differences in the processes of learning and extinction of a conditioned passive avoidance reaction in male and female DISC1-L100P mice and control C57BL/6 mice. Male and female mice of both strains were found to achieve good learning of the conditioned passive avoidance reaction, though they differed in the extinction of the memory of fear, i.e., the ability to form a new memory trace regarding the safety of the previously punished dark sector of the apparatus in a repeat test procedure. A deficit in the extinction of the conditioned passive avoidance reaction was found in female DISC1-L100P and C57BL/6 mice as compared with males. At the same time, interstrain differences were found in the dynamics of the extinction of this reaction in female mice of both strains. DISC1-L100P males were also found to differ from controls in terms of the time it took to achieve complete extinction of the reaction.

AB - We report here studies of sex-related and interstrain differences in the processes of learning and extinction of a conditioned passive avoidance reaction in male and female DISC1-L100P mice and control C57BL/6 mice. Male and female mice of both strains were found to achieve good learning of the conditioned passive avoidance reaction, though they differed in the extinction of the memory of fear, i.e., the ability to form a new memory trace regarding the safety of the previously punished dark sector of the apparatus in a repeat test procedure. A deficit in the extinction of the conditioned passive avoidance reaction was found in female DISC1-L100P and C57BL/6 mice as compared with males. At the same time, interstrain differences were found in the dynamics of the extinction of this reaction in female mice of both strains. DISC1-L100P males were also found to differ from controls in terms of the time it took to achieve complete extinction of the reaction.

KW - DISC1-L100P and C57BL/6 mice

KW - conditioned passive avoidance reaction

KW - extinction

KW - fear

KW - schizophrenia

KW - sex-related differences

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85180196373&origin=inward&txGid=67a5cb4282b16ad4ab8324a97256bb14

UR - https://www.mendeley.com/catalogue/d58d57a3-85fe-3ec4-b99f-f8b3e737d369/

U2 - 10.1007/s11055-023-01541-2

DO - 10.1007/s11055-023-01541-2

M3 - Article

VL - 53

SP - 1478

EP - 1482

JO - Neuroscience and Behavioral Physiology

JF - Neuroscience and Behavioral Physiology

SN - 0097-0549

IS - 8

ER -