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rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer. / Degtyareva, A. O.; Leberfarb, E. Y.; Efimova, E. G. и др.

в: Bulletin of Experimental Biology and Medicine, Том 169, № 1, 01.05.2020, стр. 81-84.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Degtyareva, AO, Leberfarb, EY, Efimova, EG, Brusentsov, II, Usova, AV, Lushnikova, EL & Merkulova, TI 2020, 'rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer', Bulletin of Experimental Biology and Medicine, Том. 169, № 1, стр. 81-84. https://doi.org/10.1007/s10517-020-04829-2

APA

Degtyareva, A. O., Leberfarb, E. Y., Efimova, E. G., Brusentsov, I. I., Usova, A. V., Lushnikova, E. L., & Merkulova, T. I. (2020). rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer. Bulletin of Experimental Biology and Medicine, 169(1), 81-84. https://doi.org/10.1007/s10517-020-04829-2

Vancouver

Degtyareva AO, Leberfarb EY, Efimova EG, Brusentsov II, Usova AV, Lushnikova EL и др. rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer. Bulletin of Experimental Biology and Medicine. 2020 май 1;169(1):81-84. doi: 10.1007/s10517-020-04829-2

Author

Degtyareva, A. O. ; Leberfarb, E. Y. ; Efimova, E. G. и др. / rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer. в: Bulletin of Experimental Biology and Medicine. 2020 ; Том 169, № 1. стр. 81-84.

BibTeX

@article{982e97ab8e5742bf8781253381e8a07d,
title = "rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer",
abstract = "We analyzed association of potentially regulatory polymorphisms (rs590352, rs11542583, rs3829202, rs207258, and rs4796672) with breast cancer. A significant association was found between this disease and rs2072580T>A (p=0.001) located in the overlapping promoter regions of the SART3 and ISCU genes. In women with AA and AT genotypes, the risk of breast cancer is higher by 6.7 times (p=0.001) and 12 times (p=0.001), respectively, in comparison with TT genotype. Under a codominant model of inheritance (AT vs AA+TT), the risk of breast cancer was increased by 4.2 times (р=0.001) for the AT genotype. Under a recessive model of inheritance (TT vs AA+TT), the risk of disease was 10-fold higher (р=0.001) for the TT genotype. It has been demonstrated that the T>A substitution affects the binding properties of transcription factors CREB1 and REST.",
keywords = "breast cancer, genotyping, ISCU, regulatory single-nucleotide polymorphisms, SART3",
author = "Degtyareva, {A. O.} and Leberfarb, {E. Y.} and Efimova, {E. G.} and Brusentsov, {I. I.} and Usova, {A. V.} and Lushnikova, {E. L.} and Merkulova, {T. I.}",
year = "2020",
month = may,
day = "1",
doi = "10.1007/s10517-020-04829-2",
language = "English",
volume = "169",
pages = "81--84",
journal = "Bulletin of Experimental Biology and Medicine",
issn = "0007-4888",
publisher = "Springer New York",
number = "1",

}

RIS

TY - JOUR

T1 - rs2072580T>A Polymorphism in the Overlapping Promoter Regions of the SART3 and ISCU Genes Associated with the Risk of Breast Cancer

AU - Degtyareva, A. O.

AU - Leberfarb, E. Y.

AU - Efimova, E. G.

AU - Brusentsov, I. I.

AU - Usova, A. V.

AU - Lushnikova, E. L.

AU - Merkulova, T. I.

PY - 2020/5/1

Y1 - 2020/5/1

N2 - We analyzed association of potentially regulatory polymorphisms (rs590352, rs11542583, rs3829202, rs207258, and rs4796672) with breast cancer. A significant association was found between this disease and rs2072580T>A (p=0.001) located in the overlapping promoter regions of the SART3 and ISCU genes. In women with AA and AT genotypes, the risk of breast cancer is higher by 6.7 times (p=0.001) and 12 times (p=0.001), respectively, in comparison with TT genotype. Under a codominant model of inheritance (AT vs AA+TT), the risk of breast cancer was increased by 4.2 times (р=0.001) for the AT genotype. Under a recessive model of inheritance (TT vs AA+TT), the risk of disease was 10-fold higher (р=0.001) for the TT genotype. It has been demonstrated that the T>A substitution affects the binding properties of transcription factors CREB1 and REST.

AB - We analyzed association of potentially regulatory polymorphisms (rs590352, rs11542583, rs3829202, rs207258, and rs4796672) with breast cancer. A significant association was found between this disease and rs2072580T>A (p=0.001) located in the overlapping promoter regions of the SART3 and ISCU genes. In women with AA and AT genotypes, the risk of breast cancer is higher by 6.7 times (p=0.001) and 12 times (p=0.001), respectively, in comparison with TT genotype. Under a codominant model of inheritance (AT vs AA+TT), the risk of breast cancer was increased by 4.2 times (р=0.001) for the AT genotype. Under a recessive model of inheritance (TT vs AA+TT), the risk of disease was 10-fold higher (р=0.001) for the TT genotype. It has been demonstrated that the T>A substitution affects the binding properties of transcription factors CREB1 and REST.

KW - breast cancer

KW - genotyping

KW - ISCU

KW - regulatory single-nucleotide polymorphisms

KW - SART3

UR - http://www.scopus.com/inward/record.url?scp=85085959385&partnerID=8YFLogxK

U2 - 10.1007/s10517-020-04829-2

DO - 10.1007/s10517-020-04829-2

M3 - Article

C2 - 32495170

AN - SCOPUS:85085959385

VL - 169

SP - 81

EP - 84

JO - Bulletin of Experimental Biology and Medicine

JF - Bulletin of Experimental Biology and Medicine

SN - 0007-4888

IS - 1

ER -

ID: 24517913