Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin. / Perevalova, Alina M.; Gulyaeva, Lyudmila F.; Pustylnyak, Vladimir O.
в: International Journal of Molecular Sciences, Том 25, № 4, 2153, 02.2024.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Roles of Interferon Regulatory Factor 1 in Tumor Progression and Regression: Two Sides of a Coin
AU - Perevalova, Alina M.
AU - Gulyaeva, Lyudmila F.
AU - Pustylnyak, Vladimir O.
N1 - This research was funded by the RUSSIAN SCIENCE FOUNDATION, grant number 22-15-00065.
PY - 2024/2
Y1 - 2024/2
N2 - IRF1 is a transcription factor well known for its role in IFN signaling. Although IRF1 was initially identified for its involvement in inflammatory processes, there is now evidence that it provides a function in carcinogenesis as well. IRF1 has been shown to affect several important antitumor mechanisms, such as induction of apoptosis, cell cycle arrest, remodeling of tumor immune microenvironment, suppression of telomerase activity, suppression of angiogenesis and others. Nevertheless, the opposite effects of IRF1 on tumor growth have also been demonstrated. In particular, the “immune checkpoint” molecule PD-L1, which is responsible for tumor immune evasion, has IRF1 as a major transcriptional regulator. These and several other properties of IRF1, including its proposed association with response and resistance to immunotherapy and several chemotherapeutic drugs, make it a promising object for further research. Numerous mechanisms of IRF1 regulation in cancer have been identified, including genetic, epigenetic, transcriptional, post-transcriptional, and post-translational mechanisms, although their significance for tumor progression remains to be explored. This review will focus on the established tumor-suppressive and tumor-promoting functions of IRF1, as well as the molecular mechanisms of IRF1 regulation identified in various cancers.
AB - IRF1 is a transcription factor well known for its role in IFN signaling. Although IRF1 was initially identified for its involvement in inflammatory processes, there is now evidence that it provides a function in carcinogenesis as well. IRF1 has been shown to affect several important antitumor mechanisms, such as induction of apoptosis, cell cycle arrest, remodeling of tumor immune microenvironment, suppression of telomerase activity, suppression of angiogenesis and others. Nevertheless, the opposite effects of IRF1 on tumor growth have also been demonstrated. In particular, the “immune checkpoint” molecule PD-L1, which is responsible for tumor immune evasion, has IRF1 as a major transcriptional regulator. These and several other properties of IRF1, including its proposed association with response and resistance to immunotherapy and several chemotherapeutic drugs, make it a promising object for further research. Numerous mechanisms of IRF1 regulation in cancer have been identified, including genetic, epigenetic, transcriptional, post-transcriptional, and post-translational mechanisms, although their significance for tumor progression remains to be explored. This review will focus on the established tumor-suppressive and tumor-promoting functions of IRF1, as well as the molecular mechanisms of IRF1 regulation identified in various cancers.
KW - IRF1
KW - cancer
KW - immunotherapy
KW - interferon
KW - Signal Transduction
KW - Humans
KW - Tumor Microenvironment
KW - Neoplasms/genetics
KW - Carcinogenesis/genetics
KW - Interferon Regulatory Factor-1/genetics
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85185855671&origin=inward&txGid=d811f1e5e30ac3bfcc9fad35f7d9a7ef
UR - https://www.webofscience.com/wos/woscc/full-record/WOS:001168362200001
UR - https://www.mendeley.com/catalogue/d3f94c8f-6863-3691-b7ed-0cb67be71db3/
U2 - 10.3390/ijms25042153
DO - 10.3390/ijms25042153
M3 - Article
C2 - 38396830
VL - 25
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
SN - 1661-6596
IS - 4
M1 - 2153
ER -
ID: 61161858