TY - JOUR

T1 - Role of phytonutrients in delaying aging of somatic lymph node

AU - Горчаков, Владимир Николаевич

AU - Горчакова, Ольга

AU - Nurmakhanova, Bayan

AU - Demchenko, Georgy

N1 - The state task of research work No FWNR-2022-0012. The work was performed on the equipment of Budker’s Institute of Nuclear Physics SB RAS (Novosibirsk), using the equipment supported by project RFMEFI62119X0022 [5].

PY - 2023/4/28

Y1 - 2023/4/28

N2 - An important task of gerontology and lymphology is to improve the function of the lymph nodes and reduce the risk of polymorbidity. In our experiment, we have shown the possibility of phytonutrient control over the lymph node work by changing of structure and trace-element profile. The purpose of the work is to assess the effect of a phytocomposition on the rate of aging of somatic lymph node by characterizing the structure and trace elements.Materials and Methods: The experiment was performed on Wistar rats with conditional division into old and young animals. Half of old animals received bioactive phytocomposition. The method of X-ray fluorescence analysis using synchrotron radiation (RFA SR) was used to determine trace elements (Mn, Fe, Cu, Zn, Se) in the inguinal lymph node. Results: Aging leads to immune failure accompanied by destabilization of compartments and trace element deficiency. Phytonutrient delivery format (flavonoids and trace elements) in the form of a plant food supplement helps to delay the onset of lymph node aging and improving trace element status. We have indicated the significant contribution of trace elements in restoring the work of the lymph node based on the total intensity coefficient of age changes. Conclusion: Phytonutrients improve functioning of the lymph node in aging. Thus, they can be employed as prospective anti-aging compounds in medical and wellness programs.

AB - An important task of gerontology and lymphology is to improve the function of the lymph nodes and reduce the risk of polymorbidity. In our experiment, we have shown the possibility of phytonutrient control over the lymph node work by changing of structure and trace-element profile. The purpose of the work is to assess the effect of a phytocomposition on the rate of aging of somatic lymph node by characterizing the structure and trace elements.Materials and Methods: The experiment was performed on Wistar rats with conditional division into old and young animals. Half of old animals received bioactive phytocomposition. The method of X-ray fluorescence analysis using synchrotron radiation (RFA SR) was used to determine trace elements (Mn, Fe, Cu, Zn, Se) in the inguinal lymph node. Results: Aging leads to immune failure accompanied by destabilization of compartments and trace element deficiency. Phytonutrient delivery format (flavonoids and trace elements) in the form of a plant food supplement helps to delay the onset of lymph node aging and improving trace element status. We have indicated the significant contribution of trace elements in restoring the work of the lymph node based on the total intensity coefficient of age changes. Conclusion: Phytonutrients improve functioning of the lymph node in aging. Thus, they can be employed as prospective anti-aging compounds in medical and wellness programs.

U2 - 10.35630/2023/13/2.406

DO - 10.35630/2023/13/2.406

M3 - Article

VL - 13

SP - 1

EP - 6

JO - Archiv Euromedica

JF - Archiv Euromedica

SN - 2193-3863

IS - 2

ER -