TY - JOUR

T1 - Rethinking the Role of DISC1 in CNS Function

T2 - Translational Cross-Taxon Insights From Rodent and Zebrafish Models

AU - Volgin, Andrey D

AU - Cheresiz, Sergey V

AU - Chizhova, Nadezhda D

AU - Smirnova, Kristina V

AU - Doroshkov, Alexey V

AU - Galstya, David S

AU - Abreu, Murilo S de

AU - Strekalova, Tatyana

AU - Lipina, Tatiana

AU - Pletnikov, Mikhail

AU - Yang, Longen

AU - Lim, Lee Wei

AU - Stewart, Adam Michael

AU - Amstislavskaya, Tamara G

AU - Kalueff, Allan V

N1 - AAAA-A16-116021010228-0/ budgetary funding for basic scientific research of the Scientific Research Institute of Neuroscience and Medicine St. Petersburg State University funds School of Science, Xi’an Jiaotong-Liverpool University Rethinking the Role of DISC1 in CNS Function: Translational Cross-Taxon Insights From Rodent and Zebrafish Models / A. D. Volgin, S. V. Cheresiz, N. D. Chizhova, K. V. Smirnova, A. V. Doroshkov, D. S. Galstya, M. S. de Abreu, T. Strekalova, T. Lipina, M. Pletnikov, L. Yang, L. Wei Lim, A. M. Stewart, T. G. Amstislavskaya, A. V. Kalueff // Journal of integrative neuroscience. - 2025. - Т. 24. № 9. - С. 43162. DOI 10.31083/JIN43162

PY - 2025/9/25

Y1 - 2025/9/25

N2 - Encoding a key 'hub' scaffolding protein, the 'Disrupted-In-Schizophrenia-1' (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.

AB - Encoding a key 'hub' scaffolding protein, the 'Disrupted-In-Schizophrenia-1' (DISC1) gene has been strongly implicated in brain development and functions. Genetic variance in this gene is associated with major neuropsychiatric disorders, including schizophrenia, bipolar disorder, and major depression. DISC1 is abundantly expressed in the brain of humans and various model organisms. Here, we discuss currently available animal models of DISC1-related brain deficits and their clinical relevance. We focus on evolutionarily conserved (shared) mechanisms and species-specific phenotypes, especially in newly developed zebrafish (Danio rerio) models, to better understand the uniquely complex role of DISC1 in the molecular pathogenesis of neurobehavioral abnormalities relevant to human neuropsychiatric disorders.

KW - Animals

KW - Zebrafish

KW - Disease Models, Animal

KW - Nerve Tissue Proteins/metabolism

KW - Humans

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105018398404&origin=inward

U2 - 10.31083/JIN43162

DO - 10.31083/JIN43162

M3 - Review article

C2 - 41074414

VL - 24

SP - 43162

JO - Journal of integrative neuroscience

JF - Journal of integrative neuroscience

SN - 0219-6352

IS - 9

ER -