TY - JOUR

T1 - Resveratrol: A Multifaceted Guardian against Anxiety and Stress Disorders-An Overview of Experimental Evidence

AU - Tseilikman, Vadim E

AU - Tseilikman, Olga B

AU - Yegorov, Oleg N

AU - Brichagina, Alina A

AU - Karpenko, Marina N

AU - Tseilikman, David V

AU - Shatilov, Vladislav A

AU - Zhukov, Maxim S

AU - Novak, Jurica

N1 - This work was supported by the Russian Scientific Foundation, Regional grant, Chelyabinsk Region (#23-15-20040).

PY - 2024/9

Y1 - 2024/9

N2 - The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data have been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological diseases, and behavioral disorders. The protective mechanisms of resveratrol, particularly in anxiety-related stress disorders, have been well documented. However, less attention has been given to the side effects of resveratrol. This review explores not only the mechanisms underlying the anxiolytic effects of resveratrol but also the mechanisms that may lead to increased anxiety following resveratrol treatment. Understanding these mechanisms is crucial for enhancing the efficacy of resveratrol in managing anxiety disorders associated with stress and PTSD.

AB - The medicinal properties of resveratrol have garnered increasing attention from researchers. Extensive data have been accumulated on its use in treating cardiovascular diseases, immune system disorders, cancer, neurological diseases, and behavioral disorders. The protective mechanisms of resveratrol, particularly in anxiety-related stress disorders, have been well documented. However, less attention has been given to the side effects of resveratrol. This review explores not only the mechanisms underlying the anxiolytic effects of resveratrol but also the mechanisms that may lead to increased anxiety following resveratrol treatment. Understanding these mechanisms is crucial for enhancing the efficacy of resveratrol in managing anxiety disorders associated with stress and PTSD.

KW - Resveratrol/pharmacology

KW - Humans

KW - Anti-Anxiety Agents/pharmacology

KW - Animals

KW - Anxiety/drug therapy

KW - Anxiety Disorders/drug therapy

KW - Stress, Psychological/drug therapy

KW - Stress Disorders, Post-Traumatic/drug therapy

KW - glucorticoids

KW - PTSD

KW - anxiety

KW - neuroinflammation

KW - limbic–hypothalamus–pituitary axis

KW - resveratrol

KW - monoamines

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85203647570&origin=inward&txGid=eed044174f04cdd2890e782586a2c257

UR - https://www.mendeley.com/catalogue/71611e54-31d2-39e4-a124-e96c542fb784/

U2 - 10.3390/nu16172856

DO - 10.3390/nu16172856

M3 - Review article

C2 - 39275174

VL - 16

JO - Nutrients

JF - Nutrients

SN - 2072-6643

IS - 17

M1 - 2856

ER -