Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Representation Analysis of miRNA in Urine Microvesicles and Cell-Free Urine in Prostate Diseases. / Zaporozhchenko, I. A.; Bryzgunova, O. E.; Lekchnov, E. A. и др.
в: Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry, Том 12, № 2, 01.04.2018, стр. 156-163.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Representation Analysis of miRNA in Urine Microvesicles and Cell-Free Urine in Prostate Diseases
AU - Zaporozhchenko, I. A.
AU - Bryzgunova, O. E.
AU - Lekchnov, E. A.
AU - Osipov, I. D.
AU - Zaripov, M. M.
AU - Yurchenko, Yu B.
AU - Yarmoschuk, S. V.
AU - Pashkovskaya, O. A.
AU - Rykova, E. Yu
AU - Zheravin, A. A.
AU - Laktionov, P. P.
PY - 2018/4/1
Y1 - 2018/4/1
N2 - Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesicles-associated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urinary extracellular vesicles and demonstrated diagnostic potential of their miRNAs. In this study, we have performed a comparative analysis of 84 miRNA in paired samples of urine microvesicles and urine supernatant from healthy men, patients with benign prostate hyperplasia, and prostate cancer patients using miRCURY LNA miRNA qPCR Panels. In all groups of patients, miRNA subsets characterized by different distribution between the urinary fractions have been found. In this context, two groups of miRNAs have been identified, which are involved in several signaling pathways including those associated with prostate cancer development.
AB - Urine of prostate cancer patients contains tumor-specific biopolymers, including protein- and microvesicles-associated miRNAs that can potentially be used as oncomarkers. Previously we have characterized urinary extracellular vesicles and demonstrated diagnostic potential of their miRNAs. In this study, we have performed a comparative analysis of 84 miRNA in paired samples of urine microvesicles and urine supernatant from healthy men, patients with benign prostate hyperplasia, and prostate cancer patients using miRCURY LNA miRNA qPCR Panels. In all groups of patients, miRNA subsets characterized by different distribution between the urinary fractions have been found. In this context, two groups of miRNAs have been identified, which are involved in several signaling pathways including those associated with prostate cancer development.
KW - exosomes
KW - microvesicles
KW - miRNA
KW - prostate cancer
KW - urine
UR - http://www.scopus.com/inward/record.url?scp=85047811650&partnerID=8YFLogxK
U2 - 10.1134/S1990750818020142
DO - 10.1134/S1990750818020142
M3 - Article
AN - SCOPUS:85047811650
VL - 12
SP - 156
EP - 163
JO - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
JF - Biochemistry (Moscow) Supplement Series B: Biomedical Chemistry
SN - 1990-7508
IS - 2
ER -
ID: 13687146