TY - JOUR

T1 - Reorganization of brain networks in olfactory groove meningioma patients: a pilot resting-state fMRI study

AU - Filimonova, Elena

AU - Pashkov, Anton

AU - Poptsova, Aleksandra

AU - Moysak, Galina

AU - Martirosyan, Azniv

AU - Prozorova, Polina

AU - Kurilov, Vladimir

AU - Rzaev, Jamil

N1 - The author(s) declare that financial support was received for the research and/or publication of this article. This study was supported by the Russian Science Foundation (RSF grant 25-25-00370).

PY - 2025/8/29

Y1 - 2025/8/29

N2 - Background: Olfactory groove meningioma (OGM) is frequently associated with neuropsychological and behavioral impairments. However, there is currently a lack of evidence on the pathobiology of these functional alterations. In this study, our objective was to evaluate functional connectivity disturbances in patients with OGMs compared to healthy controls. Methods: Nineteen patients with OGMs and twenty healthy controls were enrolled. The seed-based functional connectivity analysis used the main hubs of the default mode network (DMN), salience network (SN), and fronto-parietal network (FPN) as seeds. Region-of-interest (ROI)-to-voxel second-level analysis was conducted, revealing the most significant clusters of differences in brain functional connectivity between the groups. Results: Patients with OGMs demonstrated significant alterations in resting-state functional connectivity within the DMN, SN, and FPN compared to controls. Specifically, within the DMN, we identified abnormal connectivity patterns involving the medial prefrontal cortex bilaterally, posterior cingulate cortex bilaterally, and right posterolateral cortex. In the SN, we observed enhanced functional connectivity between the anterior cingulate cortex bilaterally and left frontal, temporal, and insular regions. Additionally, the FPN exhibited disrupted connectivity of the right posterior parietal cortex with other brain areas. Notably, some connectivity changes were related to perilesional edema volume, visual acuity, and clinical metrics (KPS and MoCA scores). Conclusion: We revealed significant alterations in DMN, SN, and FPN function in patients with olfactory groove meningiomas compared with controls. These changes were associated with clinical variables and lesion characteristics. To our knowledge, this is the first report on rs-fMRI alterations in patients with olfactory groove meningiomas.

AB - Background: Olfactory groove meningioma (OGM) is frequently associated with neuropsychological and behavioral impairments. However, there is currently a lack of evidence on the pathobiology of these functional alterations. In this study, our objective was to evaluate functional connectivity disturbances in patients with OGMs compared to healthy controls. Methods: Nineteen patients with OGMs and twenty healthy controls were enrolled. The seed-based functional connectivity analysis used the main hubs of the default mode network (DMN), salience network (SN), and fronto-parietal network (FPN) as seeds. Region-of-interest (ROI)-to-voxel second-level analysis was conducted, revealing the most significant clusters of differences in brain functional connectivity between the groups. Results: Patients with OGMs demonstrated significant alterations in resting-state functional connectivity within the DMN, SN, and FPN compared to controls. Specifically, within the DMN, we identified abnormal connectivity patterns involving the medial prefrontal cortex bilaterally, posterior cingulate cortex bilaterally, and right posterolateral cortex. In the SN, we observed enhanced functional connectivity between the anterior cingulate cortex bilaterally and left frontal, temporal, and insular regions. Additionally, the FPN exhibited disrupted connectivity of the right posterior parietal cortex with other brain areas. Notably, some connectivity changes were related to perilesional edema volume, visual acuity, and clinical metrics (KPS and MoCA scores). Conclusion: We revealed significant alterations in DMN, SN, and FPN function in patients with olfactory groove meningiomas compared with controls. These changes were associated with clinical variables and lesion characteristics. To our knowledge, this is the first report on rs-fMRI alterations in patients with olfactory groove meningiomas.

KW - CONN

KW - functional MRI

KW - functional connectivity

KW - meningioma

KW - olfactory groove meningioma

UR - https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=105016017086&origin=inward

UR - https://www.mendeley.com/catalogue/c95e02be-ad6b-391d-9dbc-3badbdf5b523/

U2 - 10.3389/fneur.2025.1644138

DO - 10.3389/fneur.2025.1644138

M3 - Article

C2 - 40948647

VL - 16

JO - Frontiers in Neurology

JF - Frontiers in Neurology

SN - 1664-2295

ER -