TY - JOUR

T1 - Reconstruction and Analysis of Gene Networks of Human Neurotransmitter Systems Reveal Genes with Contentious Manifestation for Anxiety, Depression, and Intellectual Disabilities

AU - Ivanov, Roman

AU - Zamyatin, Vladimir

AU - Klimenko, Aleksandra

AU - Matushkin, Yury

AU - Savostyanov, Alexander

AU - Lashin, Sergey

N1 - Publisher Copyright: © 2019 by the authors. Licensee MDPI, Basel, Switzerland.

PY - 2019/9/11

Y1 - 2019/9/11

N2 - BACKGROUND: The study of the biological basis of anxiety, depression, and intellectual disabilities in humans is one of the most actual problems of modern neurophysiology. Of particular interest is the study of complex interactions between molecular genetic factors, electrophysiological properties of the nervous system, and the behavioral characteristics of people. The neurobiological understanding of neuropsychiatric disorders requires not only the identification of genes that play a role in the molecular mechanisms of the occurrence and course of diseases, but also the understanding of complex interactions that occur between these genes. A systematic study of such interactions obviously contributes to the development of new methods of diagnosis, prevention, and treatment of disorders, as the orientation to allele variants of individual loci is not reliable enough, because the literature describes a number of genes, the same alleles of which can be associated with different, sometimes extremely different variants of phenotypic traits, depending on the genetic background, of their carriers, habitat, and other factors. RESULTS: In our study, we have reconstructed a series of gene networks (in the form of protein-protein interactions networks, as well as networks of transcription regulation) to build a model of the influence of complex interactions of environmental factors and genetic risk factors for intellectual disability, depression, and other disorders in human behavior. CONCLUSION: A list of candidate genes whose expression is presumably associated with environmental factors and has potentially contentious manifestation for behavioral and neurological traits is identified for further experimental verification.

AB - BACKGROUND: The study of the biological basis of anxiety, depression, and intellectual disabilities in humans is one of the most actual problems of modern neurophysiology. Of particular interest is the study of complex interactions between molecular genetic factors, electrophysiological properties of the nervous system, and the behavioral characteristics of people. The neurobiological understanding of neuropsychiatric disorders requires not only the identification of genes that play a role in the molecular mechanisms of the occurrence and course of diseases, but also the understanding of complex interactions that occur between these genes. A systematic study of such interactions obviously contributes to the development of new methods of diagnosis, prevention, and treatment of disorders, as the orientation to allele variants of individual loci is not reliable enough, because the literature describes a number of genes, the same alleles of which can be associated with different, sometimes extremely different variants of phenotypic traits, depending on the genetic background, of their carriers, habitat, and other factors. RESULTS: In our study, we have reconstructed a series of gene networks (in the form of protein-protein interactions networks, as well as networks of transcription regulation) to build a model of the influence of complex interactions of environmental factors and genetic risk factors for intellectual disability, depression, and other disorders in human behavior. CONCLUSION: A list of candidate genes whose expression is presumably associated with environmental factors and has potentially contentious manifestation for behavioral and neurological traits is identified for further experimental verification.

KW - depression

KW - gene network

KW - intellectual disabilities

KW - neurotransmitter

KW - SNP

KW - C3435T POLYMORPHISM

KW - SUSCEPTIBILITY

KW - BIPOLAR DISORDER

KW - COGNITION

KW - ABCB1 POLYMORPHISMS

KW - EPILEPSY

KW - FACTOR BDNF GENE

KW - MULTIDRUG-RESISTANCE

KW - PROMOTER

KW - ASSOCIATION

KW - Intellectual disabilities

KW - Depression

KW - Gene network

KW - Neurotransmitter

UR - http://www.scopus.com/inward/record.url?scp=85072142323&partnerID=8YFLogxK

U2 - 10.3390/genes10090699

DO - 10.3390/genes10090699

M3 - Article

C2 - 31514272

AN - SCOPUS:85072142323

VL - 10

JO - Genes

JF - Genes

SN - 2073-4425

IS - 9

M1 - 699

ER -