TY - GEN

T1 - Rates of Compartmentalization of Visceral Lymph Nodes in Aging

AU - Gorchakov, Vladimir

AU - Abdreshov, Serik

AU - Nurmakhanova, Bayan

AU - Eshmukhanbet, Anar

AU - Amansakhatova, Ekaterina

AU - Esenova, Makpal

N1 - We thank employee of the functional morphology laboratory of the lymphatic system of RICEL branch of IC&G SB RAS for their help in making histological sections of lymph nodes. © 2023 IEEE.

PY - 2023

Y1 - 2023

N2 - According to modern concepts, lymph nodes contains functional compartments. Compartments are thymus-dependent, thymus-independent zones and lymphatic sinuses. Age-induced changes of compartments depend on lymph nodes belonging in a certain lymphatic territory of the body. Lymph nodes efficiency decreases over time. Principles of compartmentalization is the necessary approach to characterizing senile lymph node depending on localization. We used histological method and statistical data analysis of dynamic rows to essessing the intensity of compartment change. The results showed visceral lymph nodes have a multi-directional change of compartments with different intensity over a certain period of time. Visceral lymph nodes differ from each other in the intensity of compartment changes from the baseline. The mesenteric lymph node undergoes stronger changes and shows a decline in lymphoid tissue and sinus system and expansion of the medullary substance (medullary cords) and capsular-trabecular base. The tracheobronchial lymph node is resistant to aging, as most compartments lag slightly behind the base level, except for the intense decline of secondary lymphoid follicles. The principle of compartmentalization characterizes the rapid development of aging in the mesenteric lymph node and slow aging in the tracheobronchial lymph node. Dynamic rows indicators and total growth coefficient prove features of aging rates for visceral lymph node. We consider that the regional specificity of aging is associated with differences in the change of visceral node compartments.

AB - According to modern concepts, lymph nodes contains functional compartments. Compartments are thymus-dependent, thymus-independent zones and lymphatic sinuses. Age-induced changes of compartments depend on lymph nodes belonging in a certain lymphatic territory of the body. Lymph nodes efficiency decreases over time. Principles of compartmentalization is the necessary approach to characterizing senile lymph node depending on localization. We used histological method and statistical data analysis of dynamic rows to essessing the intensity of compartment change. The results showed visceral lymph nodes have a multi-directional change of compartments with different intensity over a certain period of time. Visceral lymph nodes differ from each other in the intensity of compartment changes from the baseline. The mesenteric lymph node undergoes stronger changes and shows a decline in lymphoid tissue and sinus system and expansion of the medullary substance (medullary cords) and capsular-trabecular base. The tracheobronchial lymph node is resistant to aging, as most compartments lag slightly behind the base level, except for the intense decline of secondary lymphoid follicles. The principle of compartmentalization characterizes the rapid development of aging in the mesenteric lymph node and slow aging in the tracheobronchial lymph node. Dynamic rows indicators and total growth coefficient prove features of aging rates for visceral lymph node. We consider that the regional specificity of aging is associated with differences in the change of visceral node compartments.

KW - compartments

KW - gerontology

KW - lymph nodes

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85180364275&origin=inward&txGid=8a660fec2811deed46b200662adef705

UR - https://www.mendeley.com/catalogue/7b300267-daa2-30d7-9cc3-4d94cb84112c/

U2 - 10.1109/CSGB60362.2023.10329807

DO - 10.1109/CSGB60362.2023.10329807

M3 - Conference contribution

SN - 9798350307979

T3 - 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2023 - Proceedings

SP - 21

EP - 24

BT - 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine, CSGB 2023 - Proceedings

PB - Institute of Electrical and Electronics Engineers Inc.

T2 - 2023 IEEE Ural-Siberian Conference on Computational Technologies in Cognitive Science, Genomics and Biomedicine

Y2 - 28 September 2023 through 29 September 2023

ER -