TY - JOUR

T1 - Rare Forms of Vitamin D3-Binding Protein (DBP): Analytical Literature Review

AU - Levites, E. V.

AU - Kirikovich, S. S.

AU - Proskurina, A. S.

AU - Ivanov, N. A.

AU - Snegireva, Yu S.

AU - Bogachev, S. S.

N1 - This work was carried out with the support of budgetary funding under the topic of state assignment no. FWNR-2022-0016, as well as I.N. Zaitseva. Rare Forms of Vitamin D3-Binding Protein (DBP): Analytical Literature Review / E. V. Levites, S. S. Kirikovich, A. S. Proskurina [et al.] // Russian Journal of Genetics. – 2025. – Vol. 61, No. 3. – P. 257-262. – DOI 10.1134/S1022795424701631.

PY - 2025/4/29

Y1 - 2025/4/29

N2 - Abstract: The article presents an analysis of the published data on the structure and functions of vitamin D3-binding protein (DBP), which is controlled by a single gene with three clearly defined alleles Gc1-F, Gc1-S, and Gc2. The article presents information on various structural and functional variants of DBP, which are determined genetically and can undergo post-translational modification by glycosylation. One of the derivatives of vitamin D3-binding protein is its partially deglycosylated form, which exhibits properties of a specific activator of macrophages and is designated as the GcMAF factor. The article pays special attention to rare forms of DBP, detected by the isofocusing method. An assumption is made about the nature of rare forms of DBP and the mechanism of occurrence of changes underlying the appearance of these forms.

AB - Abstract: The article presents an analysis of the published data on the structure and functions of vitamin D3-binding protein (DBP), which is controlled by a single gene with three clearly defined alleles Gc1-F, Gc1-S, and Gc2. The article presents information on various structural and functional variants of DBP, which are determined genetically and can undergo post-translational modification by glycosylation. One of the derivatives of vitamin D3-binding protein is its partially deglycosylated form, which exhibits properties of a specific activator of macrophages and is designated as the GcMAF factor. The article pays special attention to rare forms of DBP, detected by the isofocusing method. An assumption is made about the nature of rare forms of DBP and the mechanism of occurrence of changes underlying the appearance of these forms.

KW - alleles

KW - deglycosylation

KW - glycosylation

KW - isoforms

KW - macrophage activating factor (GcMAF)

KW - vitamin D3-binding protein (DBP)

UR - https://www.mendeley.com/catalogue/1afb144d-7e0b-3181-9505-b8cb4777d53b/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-105004187245&origin=inward&txGid=bd87dc6d40238305cbb05543914a03dd

UR - https://elibrary.ru/item.asp?id=82021023

U2 - 10.1134/S1022795424701631

DO - 10.1134/S1022795424701631

M3 - Article

VL - 61

SP - 257

EP - 262

JO - Russian Journal of Genetics

JF - Russian Journal of Genetics

SN - 1022-7954

IS - 3

ER -