Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Pulse-Programmable Magnetic Field Sweeping of Parahydrogen-Induced Polarization by Side Arm Hydrogenation. / Joalland, Baptiste; Schmidt, Andreas B.; Kabir, Mohammad S.H. и др.
в: Analytical Chemistry, Том 92, № 1, 07.01.2020, стр. 1340-1345.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Pulse-Programmable Magnetic Field Sweeping of Parahydrogen-Induced Polarization by Side Arm Hydrogenation
AU - Joalland, Baptiste
AU - Schmidt, Andreas B.
AU - Kabir, Mohammad S.H.
AU - Chukanov, Nikita V.
AU - Kovtunov, Kirill V.
AU - Koptyug, Igor V.
AU - Hennig, Jürgen
AU - Hövener, Jan Bernd
AU - Chekmenev, Eduard Y.
N1 - Publisher Copyright: Copyright © 2019 American Chemical Society. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/1/7
Y1 - 2020/1/7
N2 - Among the hyperpolarization techniques geared toward in vivo magnetic resonance imaging, parahydrogen-induced polarization (PHIP) shows promise due to its low cost and fast speed of contrast agent preparation. The synthesis of 13C-labeled, unsaturated precursors to perform PHIP by side arm hydrogenation has recently opened new possibilities for metabolic imaging owing to the biological compatibility of the reaction products, although the polarization transfer between the parahydrogen-derived protons and the 13C heteronucleus must yet be better understood, characterized, and eventually optimized. In this realm, a new experimental strategy incorporating pulse-programmable magnetic field sweeping and in situ detection has been developed. The approach is evaluated by measuring the 13C polarization of ethyl acetate-1-13C, i.e., the product of pairwise addition of parahydrogen to vinyl acetate-1-13C, resulting from zero-crossing magnetic field ramps of various durations, amplitudes, and step sizes. The results demonstrate (i) the profound effect these parameters have on the 1H to 13C polarization transfer efficiency and (ii) the high reproducibility of the technique.
AB - Among the hyperpolarization techniques geared toward in vivo magnetic resonance imaging, parahydrogen-induced polarization (PHIP) shows promise due to its low cost and fast speed of contrast agent preparation. The synthesis of 13C-labeled, unsaturated precursors to perform PHIP by side arm hydrogenation has recently opened new possibilities for metabolic imaging owing to the biological compatibility of the reaction products, although the polarization transfer between the parahydrogen-derived protons and the 13C heteronucleus must yet be better understood, characterized, and eventually optimized. In this realm, a new experimental strategy incorporating pulse-programmable magnetic field sweeping and in situ detection has been developed. The approach is evaluated by measuring the 13C polarization of ethyl acetate-1-13C, i.e., the product of pairwise addition of parahydrogen to vinyl acetate-1-13C, resulting from zero-crossing magnetic field ramps of various durations, amplitudes, and step sizes. The results demonstrate (i) the profound effect these parameters have on the 1H to 13C polarization transfer efficiency and (ii) the high reproducibility of the technique.
KW - TRICARBOXYLIC-ACID CYCLE
KW - IN-VIVO
KW - C-13
KW - HYPERPOLARIZATION
KW - METABOLISM
KW - ORDER
KW - TRANSFORMATION
KW - PRECURSORS
KW - RESONANCE
KW - ACETATE
UR - http://www.scopus.com/inward/record.url?scp=85077444709&partnerID=8YFLogxK
U2 - 10.1021/acs.analchem.9b04501
DO - 10.1021/acs.analchem.9b04501
M3 - Article
C2 - 31800220
AN - SCOPUS:85077444709
VL - 92
SP - 1340
EP - 1345
JO - Analytical Chemistry
JF - Analytical Chemistry
SN - 0003-2700
IS - 1
ER -
ID: 23001433