Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Psychoneuroimmunology and immunopsychiatry of zebrafish. / de Abreu, Murilo S.; Giacomini, Ana C.V.V.; Zanandrea, Rodrigo и др.
в: Psychoneuroendocrinology, Том 92, 01.06.2018, стр. 1-12.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Psychoneuroimmunology and immunopsychiatry of zebrafish
AU - de Abreu, Murilo S.
AU - Giacomini, Ana C.V.V.
AU - Zanandrea, Rodrigo
AU - dos Santos, Bruna E.
AU - Genario, Rafael
AU - de Oliveira, Gabriel G.
AU - Friend, Ashton J.
AU - Amstislavskaya, Tamara G.
AU - Kalueff, Allan V.
N1 - Copyright © 2018 Elsevier Ltd. All rights reserved.
PY - 2018/6/1
Y1 - 2018/6/1
N2 - Despite the high prevalence of neural and immune disorders, their etiology and molecular mechanisms remain poorly understood. As the zebrafish (Danio rerio) is increasingly utilized as a powerful model organism in biomedical research, mounting evidence suggests these fish as a useful tool to study neural and immune mechanisms and their interplay. Here, we discuss zebrafish neuro-immune mechanisms and their pharmacological and genetic modulation, the effect of stress on cytokines, as well as relevant models of microbiota-brain interplay. As many human brain diseases are based on complex interplay between the neural and the immune system, here we discuss zebrafish models, as well as recent successes and challenges, in this rapidly expanding field. We particularly emphasize the growing utility of zebrafish models in translational immunopsychiatry research, as they improve our understanding of pathogenetic neuro-immune interactions, thereby fostering future discovery of potential therapeutic agents.
AB - Despite the high prevalence of neural and immune disorders, their etiology and molecular mechanisms remain poorly understood. As the zebrafish (Danio rerio) is increasingly utilized as a powerful model organism in biomedical research, mounting evidence suggests these fish as a useful tool to study neural and immune mechanisms and their interplay. Here, we discuss zebrafish neuro-immune mechanisms and their pharmacological and genetic modulation, the effect of stress on cytokines, as well as relevant models of microbiota-brain interplay. As many human brain diseases are based on complex interplay between the neural and the immune system, here we discuss zebrafish models, as well as recent successes and challenges, in this rapidly expanding field. We particularly emphasize the growing utility of zebrafish models in translational immunopsychiatry research, as they improve our understanding of pathogenetic neuro-immune interactions, thereby fostering future discovery of potential therapeutic agents.
KW - CNS
KW - Cytokines
KW - Immune system
KW - Immunopsychiatry
KW - Microbiota-brain
KW - Stress
KW - DANIO-RERIO
KW - TGF-BETA
KW - IFN-GAMMA
KW - Cytolcines
KW - NECROSIS-FACTOR-ALPHA
KW - ADULT ZEBRAFISH
KW - CYTOKINE EXPRESSION
KW - TOLL-LIKE-RECEPTOR
KW - IMMUNE-SYSTEM
KW - GUT-BRAIN AXIS
KW - T-CELL DEVELOPMENT
KW - Brain
KW - Humans
KW - Brain Diseases
KW - Disease Models, Animal
KW - Translational Medical Research
KW - Zebrafish
KW - Psychoneuroimmunology/methods
KW - Animals
KW - Mental Disorders/immunology
UR - http://www.scopus.com/inward/record.url?scp=85044572632&partnerID=8YFLogxK
U2 - 10.1016/j.psyneuen.2018.03.014
DO - 10.1016/j.psyneuen.2018.03.014
M3 - Article
C2 - 29609110
AN - SCOPUS:85044572632
VL - 92
SP - 1
EP - 12
JO - Psychoneuroendocrinology
JF - Psychoneuroendocrinology
SN - 0306-4530
ER -
ID: 12300727