TY - JOUR

T1 - Prototype of Implant for Nitric Oxide Release Controlled by Infrared Radiation in Therapeutic Window

AU - Virts, Natalia A.

AU - Karogodina, Tatyana Yu

AU - Panfilov, Mikhail A.

AU - Vorob'ev, Alexey Yu

AU - Moskalensky, Alexander E.

N1 - Финансирование: Russian Science Foundation RSF Ministry of Education and Science of the Russian Federation FSUS‐2020‐0039

PY - 2025/3

Y1 - 2025/3

N2 - Local therapeutic action and targeted drug release are promising approaches compared to traditional systemic drug administration. This is especially relevant for nitric oxide (NO), as its effects change dramatically depending on concentration and cellular context. Materials capable of releasing NO in deep tissues in a controlled manner might open new therapeutic opportunities. Light-sensitive NO donors represent a fascinating class of compounds with significant potential for precise and controlled NO release. However, most of them are sensitive to visible light, with only a few examples absorbing in a near-infrared therapeutic window. Here, we present the proof-of-concept of soft implants consisting of the photon upconverting core and the outer shell loaded with visible-light triggered NO donor. The separation into two compartments results in efficient energy harvesting by the dye and effective NO release under 980 nm infrared irradiation. Such implants could be used in smart therapies implying well-controlled and localized NO release.

AB - Local therapeutic action and targeted drug release are promising approaches compared to traditional systemic drug administration. This is especially relevant for nitric oxide (NO), as its effects change dramatically depending on concentration and cellular context. Materials capable of releasing NO in deep tissues in a controlled manner might open new therapeutic opportunities. Light-sensitive NO donors represent a fascinating class of compounds with significant potential for precise and controlled NO release. However, most of them are sensitive to visible light, with only a few examples absorbing in a near-infrared therapeutic window. Here, we present the proof-of-concept of soft implants consisting of the photon upconverting core and the outer shell loaded with visible-light triggered NO donor. The separation into two compartments results in efficient energy harvesting by the dye and effective NO release under 980 nm infrared irradiation. Such implants could be used in smart therapies implying well-controlled and localized NO release.

KW - Scopus

KW - nitric oxide

KW - photon upconversion

KW - photopharmacology

KW - nitric oxide

KW - photon upconversion

KW - photopharmacology

KW - Infrared Rays

KW - Humans

KW - Drug Liberation

KW - Nitric Oxide Donors/pharmacology

KW - Nitric Oxide/metabolism

UR - https://www.mendeley.com/catalogue/11a63a89-904d-33f9-8204-e13b0e0d7776/

UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85212944037&origin=inward&txGid=45c7b58539f9e6a1d6aa2f1939169bb6

U2 - 10.1002/jbio.202400455

DO - 10.1002/jbio.202400455

M3 - Article

C2 - 39722176

VL - 18

SP - e202400455

JO - Journal of Biophotonics

JF - Journal of Biophotonics

SN - 1864-063X

IS - 3

M1 - Е202400455

ER -