TY - JOUR

T1 - Probing reactions between imipramine and hydroxyl radical with the photolysis of iron(III) oxalate: Implications for the indirect photooxidation of tricyclic antidepressants in waters

AU - Erokhin, Semen E.

AU - Snytnikova, Olga A.

AU - Novikov, Mikhail V.

AU - Fedunov, Roman G.

AU - Grivin, Vyacheslav P.

AU - Yanshole, Vadim V.

AU - Xu, Jing

AU - Wu, Feng

AU - Plyusnin, Victor F.

AU - Pozdnyakov, Ivan P.

N1 - Funding Information: The financial support of the Russian Science Foundation (Grant No. RSF-NSFC 21-43-00004 ) and the National Natural Science Foundation of China (Grant No. NSFC-RSF 22061132001 ) is gratefully acknowledged. Authors also thanks the Ministry of Science and Higher Education of the Russian Federation for the access to MS equipment. Publisher Copyright: © 2021 Elsevier B.V.

PY - 2022/1/1

Y1 - 2022/1/1

N2 - Photodegradation of imipramine (IMI), a widely used tricyclic antidepressant, in the presence of Fe(III) oxalate and potassium persulfate (PS) was studied for the first time by combination of steady state and laser flash photolysis. It was demonstrated that Fe(III) oxalate system exhibits an effective photooxidation of IMI due to the formation of reactive oxygen species (ROS) with a very high quantum yield, φROS(308 nm) ∼0.3. The quantum yield of the most important ROS, hydroxyl radical, was also measured for the first time (φOH(308 nm) = 0.25 ± 0.02) as well as the rate constant of the reaction between •OH radical and IMI (kOH = (1.5 ± 0.1) ×1010 M−1s−1). Nature and spectral properties of short lived organic radicals formed in this reaction were also determined experimentally and proved by quantum-chemical calculations. At a IMI concentration of less than 10 µM it is possible to achieve full disappearance of the initial compound in Fe(III)-oxalate system. Main aromatic by-products of the IMI oxidation are connected with its consequent hydroxylation and elimination of aliphatic substituent. Complete degradation of both IMI and all aromatic byproducts needs joint application of Fe(III) oxalate and PS, as additional oxidizing agent. Combined Fe(III) oxalate – PS system demonstrates high photoactivity under UV irradiation and could be used for the effective degradation of IMI and its close analogues in aqueous media.

AB - Photodegradation of imipramine (IMI), a widely used tricyclic antidepressant, in the presence of Fe(III) oxalate and potassium persulfate (PS) was studied for the first time by combination of steady state and laser flash photolysis. It was demonstrated that Fe(III) oxalate system exhibits an effective photooxidation of IMI due to the formation of reactive oxygen species (ROS) with a very high quantum yield, φROS(308 nm) ∼0.3. The quantum yield of the most important ROS, hydroxyl radical, was also measured for the first time (φOH(308 nm) = 0.25 ± 0.02) as well as the rate constant of the reaction between •OH radical and IMI (kOH = (1.5 ± 0.1) ×1010 M−1s−1). Nature and spectral properties of short lived organic radicals formed in this reaction were also determined experimentally and proved by quantum-chemical calculations. At a IMI concentration of less than 10 µM it is possible to achieve full disappearance of the initial compound in Fe(III)-oxalate system. Main aromatic by-products of the IMI oxidation are connected with its consequent hydroxylation and elimination of aliphatic substituent. Complete degradation of both IMI and all aromatic byproducts needs joint application of Fe(III) oxalate and PS, as additional oxidizing agent. Combined Fe(III) oxalate – PS system demonstrates high photoactivity under UV irradiation and could be used for the effective degradation of IMI and its close analogues in aqueous media.

KW - AOPs

KW - Ferrioxalate complex

KW - Hydroxyl radical

KW - Imipramine

KW - Laser flash photolysis

KW - Persulfate

KW - Photodegradation

KW - Sulfate radical

UR - http://www.scopus.com/inward/record.url?scp=85116269630&partnerID=8YFLogxK

U2 - 10.1016/j.jphotochem.2021.113559

DO - 10.1016/j.jphotochem.2021.113559

M3 - Article

AN - SCOPUS:85116269630

VL - 422

JO - Journal of Photochemistry and Photobiology A: Chemistry

JF - Journal of Photochemistry and Photobiology A: Chemistry

SN - 1010-6030

M1 - 113559

ER -