TY - JOUR

T1 - Prioritization of biological processes based on the reconstruction and analysis of associative gene networks describing the response of plants to adverse environmental factors

AU - Demenkov, P. S.

AU - Oshchepkova, E. A.

AU - Ivanisenko, T. V.

AU - Ivanisenko, V. A.

N1 - Funding Information: Reconstruction and analysis of associative gene networks were carried out within the framework of the ICG SB RAS project ?Creation of new competitive potato varieties using marker-based and genomic selection methods?(AAAA-A20-120070990014-7) within the framework of the KPNI?Development of potato breeding and seed production?. The development of prioritization methods was carried out at the expense of the budget projects 0259-2021-0009 and 0259-2021-0012. Publisher Copyright: © Demenkov P.S., Oshchepkova Е.А., Ivanisenko T.V., Ivanisenko V.A., 2021 This work is licensed under a Creative Commons Attribution 4.0 License

PY - 2021/9

Y1 - 2021/9

N2 - Methods for prioritizing or ranking candidate genes according to their importance based on specific criteria via the analysis of gene networks are widely used in biomedicine to search for genes associated with diseases and to predict biomarkers, pharmacological targets and other clinically relevant molecules. These methods have also been used in other fields, particularly in crop production. This is largely due to the development of technologies to solve problems in marker-oriented and genomic selection, which requires knowledge of the molecular genetic mechanisms underlying the formation of agriculturally valuable traits. A new direction for the study of molecular genetic mechanisms is the prioritization of biological processes based on the analysis of associative gene networks. Associative gene networks are heterogeneous networks whose vertices can depict both molecular genetic objects (genes, proteins, metabolites, etc.) and the higher-level factors (biological processes, diseases, external environmental factors, etc.) related to regulatory, physicochemical or associative interactions. Using a previously developed method, biological processes involved in plant responses to increased cadmium content, saline stress and drought conditions were prioritized according to their degree of connection with the gene networks in the SOLANUM TUBEROSUM knowledge base. The prioritization results indicate that fundamental processes, such as gene expression, post-translational modifications, protein degradation, programmed cell death, photosynthesis, signal transmission and stress response play important roles in the common molecular genetic mechanisms for plant response to various adverse factors. On the other hand, a group of processes related to the development of seeds (“seeding development”) was revealed to be drought specific, while processes associated with ion transport (“ion transport”) were included in the list of responses specific to salt stress and processes associated with the metabolism of lipids were found to be involved specifically in the response to cadmium.

AB - Methods for prioritizing or ranking candidate genes according to their importance based on specific criteria via the analysis of gene networks are widely used in biomedicine to search for genes associated with diseases and to predict biomarkers, pharmacological targets and other clinically relevant molecules. These methods have also been used in other fields, particularly in crop production. This is largely due to the development of technologies to solve problems in marker-oriented and genomic selection, which requires knowledge of the molecular genetic mechanisms underlying the formation of agriculturally valuable traits. A new direction for the study of molecular genetic mechanisms is the prioritization of biological processes based on the analysis of associative gene networks. Associative gene networks are heterogeneous networks whose vertices can depict both molecular genetic objects (genes, proteins, metabolites, etc.) and the higher-level factors (biological processes, diseases, external environmental factors, etc.) related to regulatory, physicochemical or associative interactions. Using a previously developed method, biological processes involved in plant responses to increased cadmium content, saline stress and drought conditions were prioritized according to their degree of connection with the gene networks in the SOLANUM TUBEROSUM knowledge base. The prioritization results indicate that fundamental processes, such as gene expression, post-translational modifications, protein degradation, programmed cell death, photosynthesis, signal transmission and stress response play important roles in the common molecular genetic mechanisms for plant response to various adverse factors. On the other hand, a group of processes related to the development of seeds (“seeding development”) was revealed to be drought specific, while processes associated with ion transport (“ion transport”) were included in the list of responses specific to salt stress and processes associated with the metabolism of lipids were found to be involved specifically in the response to cadmium.

KW - Arabidopsis thaliana

KW - Associative gene networks

KW - Centrality of vertices

KW - Gene ontology

KW - Knowledge base solanum tuberosum

KW - Network-based prioritization methods

KW - Text mining methods

UR - http://www.scopus.com/inward/record.url?scp=85115769101&partnerID=8YFLogxK

UR - https://elibrary.ru/item.asp?id=46532288

U2 - 10.18699/VJ21.065

DO - 10.18699/VJ21.065

M3 - Article

C2 - 34723066

AN - SCOPUS:85115769101

VL - 25

SP - 580

EP - 592

JO - Вавиловский журнал генетики и селекции

JF - Вавиловский журнал генетики и селекции

SN - 2500-0462

IS - 5

M1 - 13

ER -