Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Preparation and characterization of a glycyrrhizic acid-based drug delivery system for allergen-specific immunotherapy. / Pashkina, Ekaterina; Evseenko, Veronika; Dumchenko, Natalya и др.
в: Nanomaterials, Том 12, № 1, 148, 01.01.2022.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - Preparation and characterization of a glycyrrhizic acid-based drug delivery system for allergen-specific immunotherapy
AU - Pashkina, Ekaterina
AU - Evseenko, Veronika
AU - Dumchenko, Natalya
AU - Zelikman, Maxim
AU - Aktanova, Alina
AU - Bykova, Maria
AU - Khvostov, Mikhail
AU - Dushkin, Aleksandr
AU - Kozlov, Vladimir
N1 - Funding Information: The reported study was funded by RFBR, project number 20-315-70039. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
PY - 2022/1/1
Y1 - 2022/1/1
N2 - The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. It is also known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, meaning that it could potentially enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of the supramolecular complexes (micelles) of GA with extracts of allergens holds promise for the development of new drugs for AIT.
AB - The most effective method of treating allergic diseases, aimed not at relieving symptoms, but at eliminating the cause of the disease, is allergen-specific immunotherapy (AIT). To reduce the risk of side effects and improve the delivery of allergens to the mucosa, various delivery systems, such as liposomes, dendrimers, nanoparticles, etc., can be used. To date, there are data on the creation of delivery systems based on glycyrrhizic acid (GA) and its derivatives, but such a delivery system has not been used for allergen-specific therapy until now. It is also known that GA has an anti-inflammatory effect, shifts the balance towards Th1, and increases the number of Treg cells, meaning that it could potentially enhance the anti-allergic effect of AIT and reduce the risk of unwanted side effects. Thus, the study of the immunomodulatory effect of the supramolecular complexes (micelles) of GA with extracts of allergens holds promise for the development of new drugs for AIT.
KW - Allergen-specific immunotherapy
KW - Drug delivery
KW - Glycyrrhizic acid
KW - House dust mite
UR - http://www.scopus.com/inward/record.url?scp=85122194932&partnerID=8YFLogxK
U2 - 10.3390/nano12010148
DO - 10.3390/nano12010148
M3 - Article
C2 - 35010098
AN - SCOPUS:85122194932
VL - 12
JO - Nanomaterials
JF - Nanomaterials
SN - 2079-4991
IS - 1
M1 - 148
ER -
ID: 35243550