Standard

Platelet activation near point-like source of agonist: Experimental insights and computational model. / Starodubtseva, Ezhena S.; Karogodina, Tatyana Yu; Moskalensky, Alexander E.

в: PLoS ONE, Том 19, № 10, e0308679, 01.10.2024.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

Harvard

Starodubtseva, ES, Karogodina, TY & Moskalensky, AE 2024, 'Platelet activation near point-like source of agonist: Experimental insights and computational model', PLoS ONE, Том. 19, № 10, e0308679. https://doi.org/10.1371/journal.pone.0308679

APA

Starodubtseva, E. S., Karogodina, T. Y., & Moskalensky, A. E. (2024). Platelet activation near point-like source of agonist: Experimental insights and computational model. PLoS ONE, 19(10), [e0308679]. https://doi.org/10.1371/journal.pone.0308679

Vancouver

Starodubtseva ES, Karogodina TY, Moskalensky AE. Platelet activation near point-like source of agonist: Experimental insights and computational model. PLoS ONE. 2024 окт. 1;19(10):e0308679. doi: 10.1371/journal.pone.0308679

Author

Starodubtseva, Ezhena S. ; Karogodina, Tatyana Yu ; Moskalensky, Alexander E. / Platelet activation near point-like source of agonist: Experimental insights and computational model. в: PLoS ONE. 2024 ; Том 19, № 10.

BibTeX

@article{bc975d4da04249018db60ef0e5dc2b88,
title = "Platelet activation near point-like source of agonist: Experimental insights and computational model",
abstract = "Disorders of hemostasis resulting in bleeding or thrombosis are leading cause of mortality in the world. Blood platelets are main players in hemostasis, providing the primary response to the vessel wall injury. In this case, they rapidly switch to the activated state in reaction to the exposed chemical substances such as ADP, collagen and thrombin. Molecular mechanisms of platelet activation are known, and detailed computational models are available. However, they are too complicated for large-scale problems (e.g. simulation of the thrombus growth) where less detailed models are required, which still should take into account the variation of agonist concentration and heterogeneity of platelets. In this paper, we present a simple model of the platelet population response to a spatially inhomogeneous stimulus. First, computational nodes modeling platelets are placed randomly in space. Each platelet is assigned the specific threshold for agonist, which determines whether it becomes activated at a given time. The distribution of the threshold value in a population is assumed to be log-normal. The model was validated against experimental data in a specially designed system, where the photorelease of ADP was caused by localized laser stimulus. In this system, a concentration of ADP obeys 2-dimensional Gaussian distribution which broadens due to the diffusion. The response of platelets to the point-like source of ADP is successfully described by the presented model. Our results advance the understanding of platelet function during hemostatic response. The simulation approach can be incorporated into larger computational models of thrombus formation.",
author = "Starodubtseva, {Ezhena S.} and Karogodina, {Tatyana Yu} and Moskalensky, {Alexander E.}",
year = "2024",
month = oct,
day = "1",
doi = "10.1371/journal.pone.0308679",
language = "English",
volume = "19",
journal = "PLoS ONE",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "10",

}

RIS

TY - JOUR

T1 - Platelet activation near point-like source of agonist: Experimental insights and computational model

AU - Starodubtseva, Ezhena S.

AU - Karogodina, Tatyana Yu

AU - Moskalensky, Alexander E.

PY - 2024/10/1

Y1 - 2024/10/1

N2 - Disorders of hemostasis resulting in bleeding or thrombosis are leading cause of mortality in the world. Blood platelets are main players in hemostasis, providing the primary response to the vessel wall injury. In this case, they rapidly switch to the activated state in reaction to the exposed chemical substances such as ADP, collagen and thrombin. Molecular mechanisms of platelet activation are known, and detailed computational models are available. However, they are too complicated for large-scale problems (e.g. simulation of the thrombus growth) where less detailed models are required, which still should take into account the variation of agonist concentration and heterogeneity of platelets. In this paper, we present a simple model of the platelet population response to a spatially inhomogeneous stimulus. First, computational nodes modeling platelets are placed randomly in space. Each platelet is assigned the specific threshold for agonist, which determines whether it becomes activated at a given time. The distribution of the threshold value in a population is assumed to be log-normal. The model was validated against experimental data in a specially designed system, where the photorelease of ADP was caused by localized laser stimulus. In this system, a concentration of ADP obeys 2-dimensional Gaussian distribution which broadens due to the diffusion. The response of platelets to the point-like source of ADP is successfully described by the presented model. Our results advance the understanding of platelet function during hemostatic response. The simulation approach can be incorporated into larger computational models of thrombus formation.

AB - Disorders of hemostasis resulting in bleeding or thrombosis are leading cause of mortality in the world. Blood platelets are main players in hemostasis, providing the primary response to the vessel wall injury. In this case, they rapidly switch to the activated state in reaction to the exposed chemical substances such as ADP, collagen and thrombin. Molecular mechanisms of platelet activation are known, and detailed computational models are available. However, they are too complicated for large-scale problems (e.g. simulation of the thrombus growth) where less detailed models are required, which still should take into account the variation of agonist concentration and heterogeneity of platelets. In this paper, we present a simple model of the platelet population response to a spatially inhomogeneous stimulus. First, computational nodes modeling platelets are placed randomly in space. Each platelet is assigned the specific threshold for agonist, which determines whether it becomes activated at a given time. The distribution of the threshold value in a population is assumed to be log-normal. The model was validated against experimental data in a specially designed system, where the photorelease of ADP was caused by localized laser stimulus. In this system, a concentration of ADP obeys 2-dimensional Gaussian distribution which broadens due to the diffusion. The response of platelets to the point-like source of ADP is successfully described by the presented model. Our results advance the understanding of platelet function during hemostatic response. The simulation approach can be incorporated into larger computational models of thrombus formation.

UR - https://www.mendeley.com/catalogue/057b6b57-8a0e-388b-b102-2865448200f9/

U2 - 10.1371/journal.pone.0308679

DO - 10.1371/journal.pone.0308679

M3 - Article

C2 - 39361659

VL - 19

JO - PLoS ONE

JF - PLoS ONE

SN - 1932-6203

IS - 10

M1 - e0308679

ER -

ID: 60794133