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Photolysis of dimethoxynitrobenzyl-"caged" acids yields fluorescent products. / Vorob'ev, Aleksey Yu; Dranova, Tatyana Yu; Moskalensky, Alexander E.

в: Scientific Reports, Том 9, № 1, 13421, 17.09.2019, стр. 13421.

Результаты исследований: Научные публикации в периодических изданияхстатьяРецензирование

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Vorob'ev AY, Dranova TY, Moskalensky AE. Photolysis of dimethoxynitrobenzyl-"caged" acids yields fluorescent products. Scientific Reports. 2019 сент. 17;9(1):13421. 13421. doi: 10.1038/s41598-019-49845-z

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BibTeX

@article{bc33a63d316c414ca970089eb25e8380,
title = "Photolysis of dimethoxynitrobenzyl-{"}caged{"} acids yields fluorescent products",
abstract = "Carboxylic acids conjugated with 4,5-dimethoxy-2-nitrobenzyl photoremovable protecting group are well known and widely used for biological studies. In this paper, we study the photolysis of likewise {"}caged{"} acetic, caprylic and arachidonic acids. Unexpectedly, we observed huge growth of fluorescence emission at ~430 nm during photolysis. Following further UV irradiation, a product with fluorescence at longer wavelength was formed (470 nm excitation / ~500-600 nm emission). While it may be used to monitor the {"}uncaging{"}, these fluorescent products may interfere with widespread dyes such as fluorescein in biomedical experiments. This effect might be negligible if the photolysis products dissolve in the medium. On the other hand, we observed that arachidonic and caprylic acids derivatives self-organize in emulsion droplets in water environment due to long lipophilic chains. Illumination of droplets by UV rapidly induces orange fluorescence excited by 488 nm light. This fluorescence turn-on was fast (~0.1 s) and apparently caused by the accumulation of water-insoluble fluorescent residuals inside droplets. These self-organized lipophilic structures with fluorescence turn-on capability may be of interest for biomedical and other application. We have identified and hypothesized some compounds which may be responsible for the observed fluorescense.",
keywords = "BEARING, MICELLES, STATE",
author = "Vorob'ev, {Aleksey Yu} and Dranova, {Tatyana Yu} and Moskalensky, {Alexander E.}",
year = "2019",
month = sep,
day = "17",
doi = "10.1038/s41598-019-49845-z",
language = "English",
volume = "9",
pages = "13421",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",
number = "1",

}

RIS

TY - JOUR

T1 - Photolysis of dimethoxynitrobenzyl-"caged" acids yields fluorescent products

AU - Vorob'ev, Aleksey Yu

AU - Dranova, Tatyana Yu

AU - Moskalensky, Alexander E.

PY - 2019/9/17

Y1 - 2019/9/17

N2 - Carboxylic acids conjugated with 4,5-dimethoxy-2-nitrobenzyl photoremovable protecting group are well known and widely used for biological studies. In this paper, we study the photolysis of likewise "caged" acetic, caprylic and arachidonic acids. Unexpectedly, we observed huge growth of fluorescence emission at ~430 nm during photolysis. Following further UV irradiation, a product with fluorescence at longer wavelength was formed (470 nm excitation / ~500-600 nm emission). While it may be used to monitor the "uncaging", these fluorescent products may interfere with widespread dyes such as fluorescein in biomedical experiments. This effect might be negligible if the photolysis products dissolve in the medium. On the other hand, we observed that arachidonic and caprylic acids derivatives self-organize in emulsion droplets in water environment due to long lipophilic chains. Illumination of droplets by UV rapidly induces orange fluorescence excited by 488 nm light. This fluorescence turn-on was fast (~0.1 s) and apparently caused by the accumulation of water-insoluble fluorescent residuals inside droplets. These self-organized lipophilic structures with fluorescence turn-on capability may be of interest for biomedical and other application. We have identified and hypothesized some compounds which may be responsible for the observed fluorescense.

AB - Carboxylic acids conjugated with 4,5-dimethoxy-2-nitrobenzyl photoremovable protecting group are well known and widely used for biological studies. In this paper, we study the photolysis of likewise "caged" acetic, caprylic and arachidonic acids. Unexpectedly, we observed huge growth of fluorescence emission at ~430 nm during photolysis. Following further UV irradiation, a product with fluorescence at longer wavelength was formed (470 nm excitation / ~500-600 nm emission). While it may be used to monitor the "uncaging", these fluorescent products may interfere with widespread dyes such as fluorescein in biomedical experiments. This effect might be negligible if the photolysis products dissolve in the medium. On the other hand, we observed that arachidonic and caprylic acids derivatives self-organize in emulsion droplets in water environment due to long lipophilic chains. Illumination of droplets by UV rapidly induces orange fluorescence excited by 488 nm light. This fluorescence turn-on was fast (~0.1 s) and apparently caused by the accumulation of water-insoluble fluorescent residuals inside droplets. These self-organized lipophilic structures with fluorescence turn-on capability may be of interest for biomedical and other application. We have identified and hypothesized some compounds which may be responsible for the observed fluorescense.

KW - BEARING

KW - MICELLES

KW - STATE

UR - http://www.scopus.com/inward/record.url?scp=85072273468&partnerID=8YFLogxK

U2 - 10.1038/s41598-019-49845-z

DO - 10.1038/s41598-019-49845-z

M3 - Article

C2 - 31530869

AN - SCOPUS:85072273468

VL - 9

SP - 13421

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 13421

ER -

ID: 21610211