Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
Photocontrolled release of nitric oxide for precise management of NO concentration in a solution. / Жермоленко, Егор Олегович; Карогодина, Татьяна Юрьевна; Воробьев, Алексей Юрьевич и др.
в: Materials Today Chemistry, Том 29, 101445, 04.2023.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
}
TY - JOUR
T1 - Photocontrolled release of nitric oxide for precise management of NO concentration in a solution
AU - Жермоленко, Егор Олегович
AU - Карогодина, Татьяна Юрьевна
AU - Воробьев, Алексей Юрьевич
AU - Панфилов, Михаил Андреевич
AU - Москаленский, Александр Ефимович
N1 - The study was supported by the Russian Science Foundation (grant # 18-15-00049).
PY - 2023/4
Y1 - 2023/4
N2 - Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short half-life and local action impede direct application in medical practice. Light-controllable NO releasers are promising for the development of smart therapies. Here, we present novel aza-BODIPY derivative containing N-nitroso moiety, which shows efficient and reversible release of NO under red light. Using this molecule, we demonstrate a system for precise management of NO concentration in aqueous solution in vitro using the feedback loop with optical control. Our results could serve as the basis for the development of novel therapeutic methods.
AB - Nitric oxide (NO) is a unique biochemical mediator involved in the regulation of vital processes. Its short half-life and local action impede direct application in medical practice. Light-controllable NO releasers are promising for the development of smart therapies. Here, we present novel aza-BODIPY derivative containing N-nitroso moiety, which shows efficient and reversible release of NO under red light. Using this molecule, we demonstrate a system for precise management of NO concentration in aqueous solution in vitro using the feedback loop with optical control. Our results could serve as the basis for the development of novel therapeutic methods.
KW - nitric oxide, NO donors, aza-BODIPY
UR - https://www.scopus.com/record/display.uri?eid=2-s2.0-85149828946&origin=inward&txGid=aac2186ee6409d8e75f01c9b160a884a
U2 - 10.1016/j.mtchem.2023.101445
DO - 10.1016/j.mtchem.2023.101445
M3 - Article
VL - 29
JO - Materials Today Chemistry
JF - Materials Today Chemistry
SN - 2468-5194
M1 - 101445
ER -
ID: 55420770