TY - GEN

T1 - Perspectives of boron-neutron capture therapy of malignant brain tumors

AU - Kanygin, V. V.

AU - Kichigin, A. I.

AU - Krivoshapkin, A. L.

AU - Taskaev, S. Yu

PY - 2017/9/28

Y1 - 2017/9/28

N2 - Boron neutron capture therapy (BNCT) is characterized by a selective effect directly on the cells of malignant tumors. The carried out research showed the perspective of the given kind of therapy concerning malignant tumors of the brain. However, the introduction of BNCT into clinical practice is hampered by the lack of a single protocol for the treatment of patients and the difficulty in using nuclear reactors to produce a neutron beam. This problem can be solved by using a compact accelerator as a source of neutrons, with the possibility of installation in a medical institution. Such a neutron accelerator for BNCT was developed at Budker Institute of Nuclear Physics, Novosibirsk. A neutron beam was obtained on this accelerator, which fully complies with the requirements of BNCT, as confirmed by studies on cell cultures and experiments with laboratory animals. The conducted experiments showed the relative safety of the method with the absence of negative effects on cell cultures and living organisms, and also confirmed the effectiveness of BNCT for malignant brain tumors.

AB - Boron neutron capture therapy (BNCT) is characterized by a selective effect directly on the cells of malignant tumors. The carried out research showed the perspective of the given kind of therapy concerning malignant tumors of the brain. However, the introduction of BNCT into clinical practice is hampered by the lack of a single protocol for the treatment of patients and the difficulty in using nuclear reactors to produce a neutron beam. This problem can be solved by using a compact accelerator as a source of neutrons, with the possibility of installation in a medical institution. Such a neutron accelerator for BNCT was developed at Budker Institute of Nuclear Physics, Novosibirsk. A neutron beam was obtained on this accelerator, which fully complies with the requirements of BNCT, as confirmed by studies on cell cultures and experiments with laboratory animals. The conducted experiments showed the relative safety of the method with the absence of negative effects on cell cultures and living organisms, and also confirmed the effectiveness of BNCT for malignant brain tumors.

KW - GLIOBLASTOMA-MULTIFORME

KW - BORONOPHENYLALANINE

KW - DELIVERY

KW - BEAM

KW - BNCT

KW - MELANOMA

KW - STRATEGY

UR - http://www.scopus.com/inward/record.url?scp=85041695760&partnerID=8YFLogxK

U2 - 10.1063/1.5001609

DO - 10.1063/1.5001609

M3 - Conference contribution

AN - SCOPUS:85041695760

VL - 1882

T3 - AIP Conference Proceedings

BT - Physics of Cancer

A2 - Gutmanas, EY

A2 - Naimark, OB

A2 - Sharkeev, YP

PB - American Institute of Physics Inc.

T2 - International Conference on Physics of Cancer: Interdisciplinary Problems and Clinical Applications, PC IPCA 2017

Y2 - 23 May 2017 through 26 May 2017

ER -