TY - JOUR

T1 - Personalized numerical simulation for hemodynamics of abdominal aortic aneurysm: analysis of simulation results sensitivity to the input boundary conditions

AU - Fedotova, Ya V.

AU - Epifanov, R. Yu

AU - Volkova, I. I.

AU - Maus, M. S.

AU - Nikitin, N. A.

AU - Aivazov, S. A.

AU - Khrebtov, M. Yu

AU - Karpenko, A. A.

AU - Mullyadzhanov, R. I.

N1 - Research was supported by the Russian Science Foundation (Project No. 21-15-00091). The computer code was developed in the framework of state assignment for the Institute of Thermophysics SB RAS (FWNS-2022-0009).

PY - 2024/3

Y1 - 2024/3

N2 - The analysis was performed for input condition sensitivity of hemodynamic simulation performed for a zone of abdominal aortic aneurysm. We took three versions of patient-specific configurations of aneurysm decease and computed the haemodynamics with different spatial and velocity profiles at the aorta inlet. Their impact on hemodynamic characteristics was evaluated. At total, the study was performed for three spatial variants (uniform, parabolic, and parabolic-and-secondary-flow velocity profiles) and three versions of time behavior of velocity profiles: this produces nine cases for every of three chosen geometries. The study demonstrated that one can neglect the impact of the spatial profile for inlet velocity (including the non-coaxial velocity vector components). Meanwhile, the value of reverse diastolic flow is significant for the solution. However, simulation in the zone of abdominal aortic aneurysm does not demonstrate great differences in simulation results for the values of wall shear stress and velocity for the data averaged over a cardiac cycle. For the distribution of the oscillation index of shear, the maximum deviation from the basic solution is about ∼ 10 %, which is quite acceptable for clinical applications.

AB - The analysis was performed for input condition sensitivity of hemodynamic simulation performed for a zone of abdominal aortic aneurysm. We took three versions of patient-specific configurations of aneurysm decease and computed the haemodynamics with different spatial and velocity profiles at the aorta inlet. Their impact on hemodynamic characteristics was evaluated. At total, the study was performed for three spatial variants (uniform, parabolic, and parabolic-and-secondary-flow velocity profiles) and three versions of time behavior of velocity profiles: this produces nine cases for every of three chosen geometries. The study demonstrated that one can neglect the impact of the spatial profile for inlet velocity (including the non-coaxial velocity vector components). Meanwhile, the value of reverse diastolic flow is significant for the solution. However, simulation in the zone of abdominal aortic aneurysm does not demonstrate great differences in simulation results for the values of wall shear stress and velocity for the data averaged over a cardiac cycle. For the distribution of the oscillation index of shear, the maximum deviation from the basic solution is about ∼ 10 %, which is quite acceptable for clinical applications.

KW - CFD simulation

KW - Navier-Stokes equations

KW - abdominal aortic aneurysm

KW - boundary conditions

KW - personalized hemodynamics

UR - https://www.mendeley.com/catalogue/676ad9a2-3dbd-3d27-ae8a-696c246b84ba/

U2 - 10.1134/S0869864324020161

DO - 10.1134/S0869864324020161

M3 - Article

VL - 31

SP - 375

EP - 391

JO - Thermophysics and Aeromechanics

JF - Thermophysics and Aeromechanics

SN - 0869-8643

IS - 2

ER -