TY - JOUR

T1 - Peculiarities of Fear Memory Extinction in Male and Female Disc1-Q31L Mice

AU - Chizhova, N. D.

AU - Smirnova, K. V.

AU - Dubrovina, N. I.

AU - Kalueff, A. V.

AU - Amstislavskaya, T. G.

N1 - Peculiarities of Fear Memory Extinction in Male and Female Disc1-Q31L Mice / N. D. Chizhova, K. V. Smirnova, N. I. Dubrovina [et al.] // Journal of Evolutionary Biochemistry and Physiology. – 2023. – Vol. 59, No. 6. – P. 2338-2345. – DOI 10.1134/s0022093023060340. This work was supported by budgetary funding for basic scientific research at the Scientific Research Institute of Neurosciences and Medicine (No. 122042700001-9). No additional grants for this research project were obtained.

PY - 2023

Y1 - 2023

N2 - Depressive disorders are common psychopathologies highly comorbid with other mental diseases, especially post-traumatic stress disorder, with overt gender differences in susceptibility. The Disc1-Q31L mutant mice are characterized by depression-like behavior and disrupted molecular pathways involved in fear memory. Here, we assess the sex- and strain differences in learning and extinction of a conditioned passive avoidance response (CPAR) in male and female Disc1-Q31L mice vs. control C57BL/6 mice. Overall, male and female mice of both strains learned equally well but differed in fear memory extinction, i.e. the ability to form a new safety memory trace in the dark compartment of the test apparatus, previously associated with aversion. C57BL/6 female mice revealed poorer CPAR extinction than males, while both sexes showed strain differences in the extinction dynamics. While Disc1-Q31L male mice reached total extinction later than C57BL/6 males, Disc1-Q31L females exhibited no extinction throughout all 24 testing days. Collectively, this not only supports the role of Disc1 in fear memory extinction but also shows sex-dependent impact of its Q31L mutation in this process.

AB - Depressive disorders are common psychopathologies highly comorbid with other mental diseases, especially post-traumatic stress disorder, with overt gender differences in susceptibility. The Disc1-Q31L mutant mice are characterized by depression-like behavior and disrupted molecular pathways involved in fear memory. Here, we assess the sex- and strain differences in learning and extinction of a conditioned passive avoidance response (CPAR) in male and female Disc1-Q31L mice vs. control C57BL/6 mice. Overall, male and female mice of both strains learned equally well but differed in fear memory extinction, i.e. the ability to form a new safety memory trace in the dark compartment of the test apparatus, previously associated with aversion. C57BL/6 female mice revealed poorer CPAR extinction than males, while both sexes showed strain differences in the extinction dynamics. While Disc1-Q31L male mice reached total extinction later than C57BL/6 males, Disc1-Q31L females exhibited no extinction throughout all 24 testing days. Collectively, this not only supports the role of Disc1 in fear memory extinction but also shows sex-dependent impact of its Q31L mutation in this process.

KW - EXTINCTION

KW - FEAR

KW - passive avoidance

KW - SEX DIFFERENCES

KW - depression

KW - DISC1-Q31L MICE

KW - C57BL/6 mice

KW - EVOLUTIONARY BIOLOGY

KW - biochemistry

KW - GENERAL

KW - ANIMAL PHYSIOLOGY

UR - https://www.mendeley.com/catalogue/0f8d5ed6-4f68-3d85-8bdc-a6467aefbc61/

UR - https://www.elibrary.ru/item.asp?id=65051958

U2 - 10.1134/s0022093023060340

DO - 10.1134/s0022093023060340

M3 - Article

VL - 59

SP - 2338

EP - 2345

JO - Journal of Evolutionary Biochemistry and Physiology

JF - Journal of Evolutionary Biochemistry and Physiology

SN - 0022-0930

IS - 6

ER -