Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
Parahydrogen-Induced Hyperpolarization of Gases. / Kovtunov, Kirill V.; Koptyug, Igor V.; Fekete, Marianna и др.
в: Angewandte Chemie - International Edition, Том 59, № 41, 05.10.2020, стр. 17788-17797.Результаты исследований: Научные публикации в периодических изданиях › обзорная статья › Рецензирование
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TY - JOUR
T1 - Parahydrogen-Induced Hyperpolarization of Gases
AU - Kovtunov, Kirill V.
AU - Koptyug, Igor V.
AU - Fekete, Marianna
AU - Duckett, Simon B.
AU - Theis, Thomas
AU - Joalland, Baptiste
AU - Chekmenev, Eduard Y.
N1 - Publisher Copyright: © 2020 Wiley-VCH GmbH Copyright: Copyright 2020 Elsevier B.V., All rights reserved.
PY - 2020/10/5
Y1 - 2020/10/5
N2 - Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen-induced polarization is a fast, highly scalable, and low-cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen-induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.
AB - Imaging of gases is a major challenge for any modality including MRI. NMR and MRI signals are directly proportional to the nuclear spin density and the degree of alignment of nuclear spins with applied static magnetic field, which is called nuclear spin polarization. The level of nuclear spin polarization is typically very low, i.e., one hundred thousandth of the potential maximum at 1.5 T and a physiologically relevant temperature. As a result, MRI typically focusses on imaging highly concentrated tissue water. Hyperpolarization methods transiently increase nuclear spin polarizations up to unity, yielding corresponding gains in MRI signal level of several orders of magnitude that enable the 3D imaging of dilute biomolecules including gases. Parahydrogen-induced polarization is a fast, highly scalable, and low-cost hyperpolarization technique. The focus of this Minireview is to highlight selected advances in the field of parahydrogen-induced polarization for the production of hyperpolarized compounds, which can be potentially employed as inhalable contrast agents.
KW - hyperpolarization
KW - MRI
KW - NMR
KW - parahydrogen
KW - spectroscopy
KW - RELAXATION
KW - PROPANE
KW - INERT
KW - SIGNAL AMPLIFICATION
KW - REVERSIBLE EXCHANGE
KW - HYDROGEN INDUCED POLARIZATION
KW - FIELD-DEPENDENCE
KW - MAGNETIC-RESONANCE
KW - EFFICIENT
KW - LIVED SPIN STATES
UR - http://www.scopus.com/inward/record.url?scp=85085978969&partnerID=8YFLogxK
U2 - 10.1002/anie.201915306
DO - 10.1002/anie.201915306
M3 - Review article
C2 - 31972061
AN - SCOPUS:85085978969
VL - 59
SP - 17788
EP - 17797
JO - Angewandte Chemie - International Edition
JF - Angewandte Chemie - International Edition
SN - 1433-7851
IS - 41
ER -
ID: 24955600