TY - JOUR

T1 - Oxygen-Sensitive Photo- and Radioluminescent Polyurethane Nanoparticles Modified with Octahedral Iodide Tungsten Clusters

AU - Bardin, Vyacheslav A.

AU - Vorotnikov, Yuri A.

AU - Stass, Dmitri V.

AU - Vorotnikova, Natalya A.

AU - Shestopalov, Michael A.

N1 - Funding Information: This research was funded by the Russian Foundation for Basic Research (No. 20-53-26008) and the Ministry of Science and Higher Education of Russia, No. 121031700321-3. N.A.V. thanks The Council for Grants of the President of the Russia (SP-3498.2021.4). Publisher Copyright: © 2022 by the authors.

PY - 2022/10

Y1 - 2022/10

N2 - The development of cancer treatment techniques able to cure tumors located deep in the body is an urgent task for scientists and physicians. One of the most promising methods is X-ray-induced photodynamic therapy (X-PDT), since X-rays have unlimited penetration through tissues. In this work, octahedral iodide tungsten clusters, combining the properties of a scintillator and photosensitizer, are considered as a key component of nanosized polyurethane (pU) particles in the production of materials promising for X-PDT. Cluster-containing pU nanoparticles obtained here demonstrate bright photo- and X-ray-induced emission in both solid and water dispersion, great efficiency in the generation of singlet oxygen, and high sensitivity regarding photoluminescence intensity in relation to oxygen concentration. Additionally, incorporation of the cluster complex into the pU matrix greatly increases its stability against hydrolysis in water and under X-rays.

AB - The development of cancer treatment techniques able to cure tumors located deep in the body is an urgent task for scientists and physicians. One of the most promising methods is X-ray-induced photodynamic therapy (X-PDT), since X-rays have unlimited penetration through tissues. In this work, octahedral iodide tungsten clusters, combining the properties of a scintillator and photosensitizer, are considered as a key component of nanosized polyurethane (pU) particles in the production of materials promising for X-PDT. Cluster-containing pU nanoparticles obtained here demonstrate bright photo- and X-ray-induced emission in both solid and water dispersion, great efficiency in the generation of singlet oxygen, and high sensitivity regarding photoluminescence intensity in relation to oxygen concentration. Additionally, incorporation of the cluster complex into the pU matrix greatly increases its stability against hydrolysis in water and under X-rays.

KW - octahedral halide tungsten cluster

KW - photoluminescence

KW - polyurethane nanoparticles

KW - radioluminescence

KW - singlet oxygen generation

UR - http://www.scopus.com/inward/record.url?scp=85140905380&partnerID=8YFLogxK

UR - https://www.mendeley.com/catalogue/0a013bcc-148d-3524-b2a0-18f80c8e2168/

U2 - 10.3390/nano12203580

DO - 10.3390/nano12203580

M3 - Article

C2 - 36296769

AN - SCOPUS:85140905380

VL - 12

JO - Nanomaterials

JF - Nanomaterials

SN - 2079-4991

IS - 20

M1 - 3580

ER -