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Origin and spread of human mitochondrial DNA haplogroup U7. / Sahakyan, Hovhannes; Kashani, Baharak Hooshiar; Tamang, Rakesh и др.

в: Scientific Reports, Том 7, 46044, 07.04.2017, стр. 46044.

Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование

Harvard

Sahakyan, H, Kashani, BH, Tamang, R, Kushniarevich, A, Francis, A, Costa, MD, Pathak, AK, Khachatryan, Z, Sharma, I, Van Oven, M, Parik, J, Hovhannisyan, H, Metspalu, E, Pennarun, E, Karmin, M, Tamm, E, Tambets, K, Bahmanimehr, A, Reisberg, T, Reidla, M, Achilli, A, Olivieri, A, Gandini, F, Perego, UA, Al-Zahery, N, Houshmand, M, Sanati, MH, Soares, P, Rai, E, Šarac, J, Šarić, T, Sharma, V, Pereira, L, Fernandes, V, Černý, V, Farjadian, S, Singh, DP, Azakli, H, Üstek, D, Trofimova, NE, Kutuev, I, Litvinov, S, Bermisheva, M, Khusnutdinova, EK, Rai, N, Singh, M, Singh, VK, Reddy, AG, Tolk, HV, Cvjetan, S, Lauc, LB, Rudan, P, Michalodimitrakis, EN, Anagnou, NP, Pappa, KI, Golubenko, MV, Orekhov, V, Borinskaya, SA, Kaldma, K, Schauer, MA, Simionescu, M, Gusar, V, Grechanina, E, Govindaraj, P, Voevoda, M, Damba, L, Sharma, S, Singh, L, Semino, O, Behar, DM, Yepiskoposyan, L, Richards, MB, Metspalu, M, Kivisild, T, Thangaraj, K, Endicott, P, Chaubey, G, Torroni, A & Villems, R 2017, 'Origin and spread of human mitochondrial DNA haplogroup U7', Scientific Reports, Том. 7, 46044, стр. 46044. https://doi.org/10.1038/srep46044

APA

Sahakyan, H., Kashani, B. H., Tamang, R., Kushniarevich, A., Francis, A., Costa, M. D., Pathak, A. K., Khachatryan, Z., Sharma, I., Van Oven, M., Parik, J., Hovhannisyan, H., Metspalu, E., Pennarun, E., Karmin, M., Tamm, E., Tambets, K., Bahmanimehr, A., Reisberg, T., ... Villems, R. (2017). Origin and spread of human mitochondrial DNA haplogroup U7. Scientific Reports, 7, 46044. [46044]. https://doi.org/10.1038/srep46044

Vancouver

Sahakyan H, Kashani BH, Tamang R, Kushniarevich A, Francis A, Costa MD и др. Origin and spread of human mitochondrial DNA haplogroup U7. Scientific Reports. 2017 апр. 7;7:46044. 46044. doi: 10.1038/srep46044

Author

Sahakyan, Hovhannes ; Kashani, Baharak Hooshiar ; Tamang, Rakesh и др. / Origin and spread of human mitochondrial DNA haplogroup U7. в: Scientific Reports. 2017 ; Том 7. стр. 46044.

BibTeX

@article{265e55eed24e4eaa9f219aa7b3d5dd77,
title = "Origin and spread of human mitochondrial DNA haplogroup U7",
abstract = "Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.",
keywords = "Bayes Theorem, DNA, Mitochondrial/genetics, Evolution, Molecular, Geography, Haplotypes/genetics, Humans, Mutation/genetics, Phylogeny, EARLY FARMERS, GENOMES SUGGEST, ANCIENT DNA, CENTRAL-EUROPE, GENETIC-ORIGIN, MTDNA VARIATION, Y-CHROMOSOME, POSITIVE SELECTION, HUNTER-GATHERERS, MOLECULAR CLOCK",
author = "Hovhannes Sahakyan and Kashani, {Baharak Hooshiar} and Rakesh Tamang and Alena Kushniarevich and Amirtharaj Francis and Costa, {Marta D.} and Pathak, {Ajai Kumar} and Zaruhi Khachatryan and Indu Sharma and {Van Oven}, Mannis and J{\"u}ri Parik and Hrant Hovhannisyan and Ene Metspalu and Erwan Pennarun and Monika Karmin and Erika Tamm and Kristiina Tambets and Ardeshir Bahmanimehr and Tuuli Reisberg and Maere Reidla and Alessandro Achilli and Anna Olivieri and Francesca Gandini and Perego, {Ugo A.} and Nadia Al-Zahery and Massoud Houshmand and Sanati, {Mohammad Hossein} and Pedro Soares and Ekta Rai and Jelena {\v S}arac and Tena {\v S}ari{\'c} and Varun Sharma and Luisa Pereira and Veronica Fernandes and Viktor {\v C}ern{\'y} and Shirin Farjadian and Singh, {Deepankar Pratap} and H{\"u}lya Azakli and Duran {\"U}stek and Trofimova, {Natalia Ekomasova} and Ildus Kutuev and Sergei Litvinov and Marina Bermisheva and Khusnutdinova, {Elza K.} and Niraj Rai and Manvendra Singh and Singh, {Vijay Kumar} and Reddy, {Alla G.} and Tolk, {Helle Viivi} and Svjetlana Cvjetan and Lauc, {Lovorka Barac} and Pavao Rudan and Michalodimitrakis, {Emmanuel N.} and Anagnou, {Nicholas P.} and Pappa, {Kalliopi I.} and Golubenko, {Maria V.} and Vladimir Orekhov and Borinskaya, {Svetlana A.} and Katrin Kaldma and Schauer, {Monica A.} and Maya Simionescu and Vladislava Gusar and Elena Grechanina and Periyasamy Govindaraj and Mikhail Voevoda and Larissa Damba and Swarkar Sharma and Lalji Singh and Ornella Semino and Behar, {Doron M.} and Levon Yepiskoposyan and Richards, {Martin B.} and Mait Metspalu and Toomas Kivisild and Kumarasamy Thangaraj and Phillip Endicott and Gyaneshwer Chaubey and Antonio Torroni and Richard Villems",
note = "Publisher Copyright: {\textcopyright} The Author(s) 2017.",
year = "2017",
month = apr,
day = "7",
doi = "10.1038/srep46044",
language = "English",
volume = "7",
pages = "46044",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "Nature Publishing Group",

}

RIS

TY - JOUR

T1 - Origin and spread of human mitochondrial DNA haplogroup U7

AU - Sahakyan, Hovhannes

AU - Kashani, Baharak Hooshiar

AU - Tamang, Rakesh

AU - Kushniarevich, Alena

AU - Francis, Amirtharaj

AU - Costa, Marta D.

AU - Pathak, Ajai Kumar

AU - Khachatryan, Zaruhi

AU - Sharma, Indu

AU - Van Oven, Mannis

AU - Parik, Jüri

AU - Hovhannisyan, Hrant

AU - Metspalu, Ene

AU - Pennarun, Erwan

AU - Karmin, Monika

AU - Tamm, Erika

AU - Tambets, Kristiina

AU - Bahmanimehr, Ardeshir

AU - Reisberg, Tuuli

AU - Reidla, Maere

AU - Achilli, Alessandro

AU - Olivieri, Anna

AU - Gandini, Francesca

AU - Perego, Ugo A.

AU - Al-Zahery, Nadia

AU - Houshmand, Massoud

AU - Sanati, Mohammad Hossein

AU - Soares, Pedro

AU - Rai, Ekta

AU - Šarac, Jelena

AU - Šarić, Tena

AU - Sharma, Varun

AU - Pereira, Luisa

AU - Fernandes, Veronica

AU - Černý, Viktor

AU - Farjadian, Shirin

AU - Singh, Deepankar Pratap

AU - Azakli, Hülya

AU - Üstek, Duran

AU - Trofimova, Natalia Ekomasova

AU - Kutuev, Ildus

AU - Litvinov, Sergei

AU - Bermisheva, Marina

AU - Khusnutdinova, Elza K.

AU - Rai, Niraj

AU - Singh, Manvendra

AU - Singh, Vijay Kumar

AU - Reddy, Alla G.

AU - Tolk, Helle Viivi

AU - Cvjetan, Svjetlana

AU - Lauc, Lovorka Barac

AU - Rudan, Pavao

AU - Michalodimitrakis, Emmanuel N.

AU - Anagnou, Nicholas P.

AU - Pappa, Kalliopi I.

AU - Golubenko, Maria V.

AU - Orekhov, Vladimir

AU - Borinskaya, Svetlana A.

AU - Kaldma, Katrin

AU - Schauer, Monica A.

AU - Simionescu, Maya

AU - Gusar, Vladislava

AU - Grechanina, Elena

AU - Govindaraj, Periyasamy

AU - Voevoda, Mikhail

AU - Damba, Larissa

AU - Sharma, Swarkar

AU - Singh, Lalji

AU - Semino, Ornella

AU - Behar, Doron M.

AU - Yepiskoposyan, Levon

AU - Richards, Martin B.

AU - Metspalu, Mait

AU - Kivisild, Toomas

AU - Thangaraj, Kumarasamy

AU - Endicott, Phillip

AU - Chaubey, Gyaneshwer

AU - Torroni, Antonio

AU - Villems, Richard

N1 - Publisher Copyright: © The Author(s) 2017.

PY - 2017/4/7

Y1 - 2017/4/7

N2 - Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.

AB - Human mitochondrial DNA haplogroup U is among the initial maternal founders in Southwest Asia and Europe and one that best indicates matrilineal genetic continuity between late Pleistocene hunter-gatherer groups and present-day populations of Europe. While most haplogroup U subclades are older than 30 thousand years, the comparatively recent coalescence time of the extant variation of haplogroup U7 (∼16-19 thousand years ago) suggests that its current distribution is the consequence of more recent dispersal events, despite its wide geographical range across Europe, the Near East and South Asia. Here we report 267 new U7 mitogenomes that - analysed alongside 100 published ones - enable us to discern at least two distinct temporal phases of dispersal, both of which most likely emanated from the Near East. The earlier one began prior to the Holocene (∼11.5 thousand years ago) towards South Asia, while the later dispersal took place more recently towards Mediterranean Europe during the Neolithic (∼8 thousand years ago). These findings imply that the carriers of haplogroup U7 spread to South Asia and Europe before the suggested Bronze Age expansion of Indo-European languages from the Pontic-Caspian Steppe region.

KW - Bayes Theorem

KW - DNA, Mitochondrial/genetics

KW - Evolution, Molecular

KW - Geography

KW - Haplotypes/genetics

KW - Humans

KW - Mutation/genetics

KW - Phylogeny

KW - EARLY FARMERS

KW - GENOMES SUGGEST

KW - ANCIENT DNA

KW - CENTRAL-EUROPE

KW - GENETIC-ORIGIN

KW - MTDNA VARIATION

KW - Y-CHROMOSOME

KW - POSITIVE SELECTION

KW - HUNTER-GATHERERS

KW - MOLECULAR CLOCK

UR - http://www.scopus.com/inward/record.url?scp=85017234632&partnerID=8YFLogxK

U2 - 10.1038/srep46044

DO - 10.1038/srep46044

M3 - Article

C2 - 28387361

AN - SCOPUS:85017234632

VL - 7

SP - 46044

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

M1 - 46044

ER -

ID: 8973431