Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
On association of the lethal yellow (AY) mutation in the agouti gene with the alterations in mouse brain and behavior. / Khotskin, Nikita V.; Plyusnina, Alexandra V.; Kulikova, Elizabeth A. и др.
в: Behavioural Brain Research, Том 359, 01.02.2019, стр. 446-456.Результаты исследований: Научные публикации в периодических изданиях › статья › Рецензирование
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TY - JOUR
T1 - On association of the lethal yellow (AY) mutation in the agouti gene with the alterations in mouse brain and behavior
AU - Khotskin, Nikita V.
AU - Plyusnina, Alexandra V.
AU - Kulikova, Elizabeth A.
AU - Bazhenova, Ekaterina Y.
AU - Fursenko, Daryia V.
AU - Sorokin, Ivan E.
AU - Kolotygin, Ilia
AU - Mormede, Pierre
AU - Terenina, Elena E.
AU - Shevelev, Oleg B.
AU - Kulikov, Alexander V.
N1 - Copyright © 2018 Elsevier B.V. All rights reserved.
PY - 2019/2/1
Y1 - 2019/2/1
N2 - Lethal yellow (AY) mutation causes obesity and type-2 diabetes in mice. Here we studied the effect of the AY mutation on the brain and behavior. The experiments were carried out on adult (11–12 weeks old) males of AY/a mice and their wild-type littermates (a/a). Mice of AY/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. At the same time, the fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in AY/a mice compared with a/a ones. Magnetic resonance imaging revealed a significant reduction of cortex volume in AY/a mice. The level of mRNA of Ptpn5 gene encoding striatal enriched tyrosine phosphatase in the frontal cortex of AY/a mice was significantly elevated compared with their wild-type littermates. This is the first report on the alterations in the brain and behavior in the AY/a mouse line. It is tempting to speculate that this mouse line can serve as a new and useful preclinical model to study neurobehavioral complications associated with obesity and type-2 diabetes.
AB - Lethal yellow (AY) mutation causes obesity and type-2 diabetes in mice. Here we studied the effect of the AY mutation on the brain and behavior. The experiments were carried out on adult (11–12 weeks old) males of AY/a mice and their wild-type littermates (a/a). Mice of AY/a and a/a genotypes did not differ in their home cage activity, sleep, food and water consumption, learning ability in the Morris water maze, anxiety in the open field and elevated plus-maze, as well as in the level of monoamines, metabolites and some genes expression in the brain. At the same time, the fat mass, depressive-like immobility in the forced swim and tail suspension tests were significantly increased in AY/a mice compared with a/a ones. Magnetic resonance imaging revealed a significant reduction of cortex volume in AY/a mice. The level of mRNA of Ptpn5 gene encoding striatal enriched tyrosine phosphatase in the frontal cortex of AY/a mice was significantly elevated compared with their wild-type littermates. This is the first report on the alterations in the brain and behavior in the AY/a mouse line. It is tempting to speculate that this mouse line can serve as a new and useful preclinical model to study neurobehavioral complications associated with obesity and type-2 diabetes.
KW - Behavior
KW - Brain
KW - Lethal yellow
KW - Mice
KW - MRI
UR - http://www.scopus.com/inward/record.url?scp=85057290933&partnerID=8YFLogxK
U2 - 10.1016/j.bbr.2018.11.013
DO - 10.1016/j.bbr.2018.11.013
M3 - Article
C2 - 30447239
AN - SCOPUS:85057290933
VL - 359
SP - 446
EP - 456
JO - Behavioural Brain Research
JF - Behavioural Brain Research
SN - 0166-4328
ER -
ID: 18069680