TY - JOUR

T1 - Octahedral iodide Mo6 cluster complex bearing thiosulfate ligands: a dual chemotherapeutic and radiodynamic agent for advanced cancer therapy

AU - Позмогова, Татьяна Николаевна

AU - Vegner, Margarita V

AU - Vorotinkov, Yuri A.

AU - Короткова, Софья Владимировна

AU - Громова, Мария Анатольевна

AU - Цыганкова, Альфия Рафаэльевна

AU - Гусельникова, Татьяна Яковлевна

AU - Vavilov, Georgy D.

AU - Kuratieva, Nataliya V.

AU - Стась, Дмитрий Владимирович

AU - Шестопалова, Лидия Владимировна

AU - Khripko, Olga

AU - Shestopalov, Aleksander M

AU - Shestopalov, Michael A.

N1 - Octahedral iodide Mo6 cluster complex bearing thiosulfate ligands: a dual chemotherapeutic and radiodynamic agent for advanced cancer therapy / T. N. Pozmogova, M. V. Vegner, Y. A. Vorotinkov, S. V. Korotkova, M. A. Gromova, A. R. Tsygankova, T. Y. Guselnikova, G. D. Vavilov, N. V. Kuratieva, D. V. Stass, L. V. Shestopalova, О. P. Khripko, A. M. Shestopalov, M. A. Shestopalov // Biomaterials Science. - 2025. DOI: 10.1039/D5BM00909J

PY - 2025/9/16

Y1 - 2025/9/16

N2 - Cancer treatment faces significant challenges due to tumor heterogeneity, drug resistance, and the limited efficacy of single-agent therapies, driving the search for novel therapeutic approaches. The water-soluble molybdenum cluster complex Na5Cs3[{Mo6I8}(S2O3)6]·3H2O, developed in this study, represents a unique compound that combines a strong chemotherapeutic effect, achieved through the controlled release of sulfur-containing gas-signaling molecules (H2S and SO2) during hydrolysis, with a radiodynamic effect, enabled by the ability of the cluster to generate singlet oxygen (1O2) under X-rays. The results of in vitro experiments confirmed significant cytostatic effects on cancer cells, while in vivo studies using Nu/J mice xenografted with HeLa tumors showed substantial tumor growth inhibition when the cluster was administered subcutaneously in combination with X-ray irradiation. Overall, the dual functionality of the cluster, along with the slow release and prolonged retention of the complex in tumor tissues, makes it a highly promising candidate for advanced cancer treatment strategies, particularly when integrated with conventional radiotherapy.

AB - Cancer treatment faces significant challenges due to tumor heterogeneity, drug resistance, and the limited efficacy of single-agent therapies, driving the search for novel therapeutic approaches. The water-soluble molybdenum cluster complex Na5Cs3[{Mo6I8}(S2O3)6]·3H2O, developed in this study, represents a unique compound that combines a strong chemotherapeutic effect, achieved through the controlled release of sulfur-containing gas-signaling molecules (H2S and SO2) during hydrolysis, with a radiodynamic effect, enabled by the ability of the cluster to generate singlet oxygen (1O2) under X-rays. The results of in vitro experiments confirmed significant cytostatic effects on cancer cells, while in vivo studies using Nu/J mice xenografted with HeLa tumors showed substantial tumor growth inhibition when the cluster was administered subcutaneously in combination with X-ray irradiation. Overall, the dual functionality of the cluster, along with the slow release and prolonged retention of the complex in tumor tissues, makes it a highly promising candidate for advanced cancer treatment strategies, particularly when integrated with conventional radiotherapy.

UR - https://pubs.rsc.org/en/content/articlelanding/2025/bm/d5bm00909j#!divAbstract

U2 - 10.1039/D5BM00909J

DO - 10.1039/D5BM00909J

M3 - Article

JO - Biomaterials Science

JF - Biomaterials Science

SN - 2047-4830

ER -