TY - JOUR

T1 - Numerical simulation of the inflammatory phase of myocardial infarction

AU - Voropaeva, O. F.

AU - Tsgoev, Ch A.

AU - Shokin, Yu I.

N1 - Publisher Copyright: © 2021, Pleiades Publishing, Ltd.

PY - 2021/5

Y1 - 2021/5

N2 - The dynamics of death of cardiac muscle cells in the acute phase of myocardial infarction is studied numerically. The problem is considered in local and spatially distributed formulations. The adequacy of the mathematical model is confirmed by the quantitative agreement between the results of numerical solution of the problem and experimental data. The adopted models are used to investigate the trigger mechanism of transition from a favorable scenario for the development of acute myocardial infarction to a scenario with a rapid increase in the level of myocardial damage on the third–fifth day of myocardial infarction. For these scenarios of the development of myocardial infarction, the process of demarcating inflammation is investigated. The results of the studies, including evaluations of the effectiveness of anti-inflammatory cytokine therapeutic strategies, are consistent with available data of laboratory studies.

AB - The dynamics of death of cardiac muscle cells in the acute phase of myocardial infarction is studied numerically. The problem is considered in local and spatially distributed formulations. The adequacy of the mathematical model is confirmed by the quantitative agreement between the results of numerical solution of the problem and experimental data. The adopted models are used to investigate the trigger mechanism of transition from a favorable scenario for the development of acute myocardial infarction to a scenario with a rapid increase in the level of myocardial damage on the third–fifth day of myocardial infarction. For these scenarios of the development of myocardial infarction, the process of demarcating inflammation is investigated. The results of the studies, including evaluations of the effectiveness of anti-inflammatory cytokine therapeutic strategies, are consistent with available data of laboratory studies.

KW - Cauchy problem

KW - demarcating inflammation

KW - fractional step method

KW - mathematical model

KW - myocardial infarction

KW - reaction–diffusion equations

KW - trigger mechanism

UR - http://www.scopus.com/inward/record.url?scp=85114697254&partnerID=8YFLogxK

U2 - 10.1134/S002189442103010X

DO - 10.1134/S002189442103010X

M3 - Article

AN - SCOPUS:85114697254

VL - 62

SP - 441

EP - 450

JO - Journal of Applied Mechanics and Technical Physics

JF - Journal of Applied Mechanics and Technical Physics

SN - 0021-8944

IS - 3

ER -