Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
Numerical simulation of fluid flow in a rotational bioreactor. / Ganimedov, V. L.; Papaeva, E. O.; Maslov, N. A. и др.
Proceedings of the XXV Conference on High-Energy Processes in Condensed Matter, HEPCM 2017: Dedicated to the 60th Anniversary of the Khristianovich Institute of Theoretical and Applied Mechanics SB RAS. ред. / Fomin. Том 1893 American Institute of Physics Inc., 2017. 030006 (AIP Conference Proceedings; Том 1893).Результаты исследований: Публикации в книгах, отчётах, сборниках, трудах конференций › статья в сборнике материалов конференции › научная › Рецензирование
}
TY - GEN
T1 - Numerical simulation of fluid flow in a rotational bioreactor
AU - Ganimedov, V. L.
AU - Papaeva, E. O.
AU - Maslov, N. A.
AU - Larionov, P. M.
PY - 2017/10/26
Y1 - 2017/10/26
N2 - Application of scaffold technology for the problem of bone tissue regeneration has great prospects in modern medicine. The influence of fluid shear stress on stem cells cultivation and its differentiation into osteoblasts is the subject of intensive research. Mathematical modeling of fluid flow in bioreactor allowed us to determine the structure of flow and estimate the level of mechanical stress on cells. The series of computations for different rotation frequencies (0.083, 0.124, 0.167, 0.2 and 0.233 Hz) was performed for the laminar flow regime approximation. It was shown that the Taylor vortices in the gap between the cylinders qualitatively change the distribution of static pressure and shear stress in the region of vortices connection. It was shown that an increase in the rotation frequency leads to an increase of the unevenness in distribution of the above mentioned functions. The obtained shear stress and static pressure dependence on the rotational frequency make it possible to choose the operating mode of the reactor depending on the provided requirements. It was shown that in the range of rotation frequencies chosen in this work (0.083 < f < 0.233 Hz), the shear stress does not exceed the known literature data (0.002-0.1 Pa).
AB - Application of scaffold technology for the problem of bone tissue regeneration has great prospects in modern medicine. The influence of fluid shear stress on stem cells cultivation and its differentiation into osteoblasts is the subject of intensive research. Mathematical modeling of fluid flow in bioreactor allowed us to determine the structure of flow and estimate the level of mechanical stress on cells. The series of computations for different rotation frequencies (0.083, 0.124, 0.167, 0.2 and 0.233 Hz) was performed for the laminar flow regime approximation. It was shown that the Taylor vortices in the gap between the cylinders qualitatively change the distribution of static pressure and shear stress in the region of vortices connection. It was shown that an increase in the rotation frequency leads to an increase of the unevenness in distribution of the above mentioned functions. The obtained shear stress and static pressure dependence on the rotational frequency make it possible to choose the operating mode of the reactor depending on the provided requirements. It was shown that in the range of rotation frequencies chosen in this work (0.083 < f < 0.233 Hz), the shear stress does not exceed the known literature data (0.002-0.1 Pa).
UR - http://www.scopus.com/inward/record.url?scp=85034257240&partnerID=8YFLogxK
U2 - 10.1063/1.5007464
DO - 10.1063/1.5007464
M3 - Conference contribution
AN - SCOPUS:85034257240
VL - 1893
T3 - AIP Conference Proceedings
BT - Proceedings of the XXV Conference on High-Energy Processes in Condensed Matter, HEPCM 2017
A2 - Fomin, null
PB - American Institute of Physics Inc.
T2 - 25th Conference on High-Energy Processes in Condensed Matter, HEPCM 2017
Y2 - 5 June 2017 through 9 June 2017
ER -
ID: 9673803